Heterogeneous allele expression of pulmonary SP-D gene in rat large intestine and other tissues

Zhenwu Lin, Joanna Floros

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Random allele expression has recently been observed for several genes including interleukins and genes of the lymphoid system. We studied the hypothesis that the surfactant protein D (SP-D) gene, an innate host defense molecule, exhibits random allele expression in a tissue-specific manner. SP-D gene expression is tissue specific in the 14 tissues studied. Study of SP-D allelic expression in several tissues revealed a balanced biallelic (BB) in lung, and, in several extrapulmonary tissues, a heterogeneous pattern: BB, imbalanced biallelic (IB), and monoallelic (MO). The results from 103 heterozygous rats showed an expression profile in large intestine of BB (22%), IB (58%), and MO (20%). Among eight families, the percent of BB in siblings varied from 0 to 41%, MO from 0 to 33%, and IB from 49 to 83%. The parent-of-origin does not play a role in SP-D allele-specific expression. However, acquired epigenetic factors, family background, or other factors may contribute to the overall pattern of expression.

Original languageEnglish (US)
Pages (from-to)235-243
Number of pages9
JournalPhysiological genomics
StatePublished - Jan 2003

All Science Journal Classification (ASJC) codes

  • Physiology
  • Genetics


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