TY - JOUR
T1 - Hexahydrobenzo[a]phenanthridines
T2 - novel dopamine D3 receptor ligands
AU - Watts, Val J.
AU - Lawler, Cindy P.
AU - Knoerzer, Timm
AU - Mayleben, Mechelle A.
AU - Neve, Kim A.
AU - Nichols, David E.
AU - Mailman, Richard B.
PY - 1993/8/3
Y1 - 1993/8/3
N2 - We report that certain substituted hexathydrobenzo[a]phenanthridines are novel high affinity ligands selective for the dopamine D3 receptor. These data demonstrate that substitutions on the heterocyclic nitrogen and the pendant phenyl ring of this nucleus cause a marked increase in both affinity and selectivity for dopamine D3 vs. D2 receptors. Thus, these compounds represent important new tools to study the pharmacology of dopamine D3 receptors, and may also provide an opportunity for the synthesis of new radioligands for dopamine D3 receptors.
AB - We report that certain substituted hexathydrobenzo[a]phenanthridines are novel high affinity ligands selective for the dopamine D3 receptor. These data demonstrate that substitutions on the heterocyclic nitrogen and the pendant phenyl ring of this nucleus cause a marked increase in both affinity and selectivity for dopamine D3 vs. D2 receptors. Thus, these compounds represent important new tools to study the pharmacology of dopamine D3 receptors, and may also provide an opportunity for the synthesis of new radioligands for dopamine D3 receptors.
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U2 - 10.1016/0014-2999(93)91012-C
DO - 10.1016/0014-2999(93)91012-C
M3 - Article
C2 - 8223910
AN - SCOPUS:0027203853
SN - 0014-2999
VL - 239
SP - 271
EP - 273
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -