HIGH INCIDENCE OF TUBERCULOSIS INFECTION IN HIV-EXPOSED CHILDREN EXITING AN ISONIAZID PREVENTIVE THERAPY TRIAL

IMPAACT P1041 Team

doi:10.1097/INF.0000000000001946

HIGH INCIDENCE OF TUBERCULOSIS INFECTION IN HIV-EXPOSED CHILDREN EXITING AN ISONIAZID PREVENTIVE THERAPY TRIAL

IMPAACT P1041 Team

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Young HIV-exposed children are at high risk for TB infection. We performed QuantiFERON-TB Gold among HIV-exposed children in South Africa at enrolment and 1-year follow-up. The incidence of TB infection was high for HIV+ (11 cases per 100 child-years) and HIV-exposed uninfected children (15 cases per 100 child-years). QuantiFERON-TB Gold may identify HIV-exposed children at risk for TB disease progression.

Original language	English (US)
Pages (from-to)	E254-E256
Journal	Pediatric Infectious Disease Journal
Volume	37
Issue number	10
DOIs	https://doi.org/10.1097/INF.0000000000001946
State	Published - Oct 1 2018

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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10.1097/INF.0000000000001946

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title = "HIGH INCIDENCE OF TUBERCULOSIS INFECTION IN HIV-EXPOSED CHILDREN EXITING AN ISONIAZID PREVENTIVE THERAPY TRIAL",

abstract = "Young HIV-exposed children are at high risk for TB infection. We performed QuantiFERON-TB Gold among HIV-exposed children in South Africa at enrolment and 1-year follow-up. The incidence of TB infection was high for HIV+ (11 cases per 100 child-years) and HIV-exposed uninfected children (15 cases per 100 child-years). QuantiFERON-TB Gold may identify HIV-exposed children at risk for TB disease progression.",

author = "{IMPAACT P1041 Team} and Cranmer, {Lisa M.} and Draper, {Heather R.} and Mandalakas, {Anna M.} and Soyeon Kim and George McSherry and Emma Krezinski and Joan Coetzee and Charles Mitchell and Sharon Nachman and {van der Linde}, Mercia and Cotton, {Mark F.} and Hesseling, {Anneke C.}",

year = "2018",

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doi = "10.1097/INF.0000000000001946",

language = "English (US)",

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AU - IMPAACT P1041 Team

AU - Cranmer, Lisa M.

AU - Draper, Heather R.

AU - Mandalakas, Anna M.

AU - Kim, Soyeon

AU - McSherry, George

AU - Krezinski, Emma

AU - Coetzee, Joan

AU - Mitchell, Charles

AU - Nachman, Sharon

AU - van der Linde, Mercia

AU - Cotton, Mark F.

AU - Hesseling, Anneke C.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Young HIV-exposed children are at high risk for TB infection. We performed QuantiFERON-TB Gold among HIV-exposed children in South Africa at enrolment and 1-year follow-up. The incidence of TB infection was high for HIV+ (11 cases per 100 child-years) and HIV-exposed uninfected children (15 cases per 100 child-years). QuantiFERON-TB Gold may identify HIV-exposed children at risk for TB disease progression.

AB - Young HIV-exposed children are at high risk for TB infection. We performed QuantiFERON-TB Gold among HIV-exposed children in South Africa at enrolment and 1-year follow-up. The incidence of TB infection was high for HIV+ (11 cases per 100 child-years) and HIV-exposed uninfected children (15 cases per 100 child-years). QuantiFERON-TB Gold may identify HIV-exposed children at risk for TB disease progression.

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HIGH INCIDENCE OF TUBERCULOSIS INFECTION IN HIV-EXPOSED CHILDREN EXITING AN ISONIAZID PREVENTIVE THERAPY TRIAL

Abstract

All Science Journal Classification (ASJC) codes

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