High levels of serum TIMP-1 correlate with advanced disease and predict for poor survival in patients with multiple myeloma treated with novel agents

Evangelos Terpos; Meletios A. Dimopoulos; Vikas Shrivastava; Kim Leitzel; Dimitrios Christoulas; Magdalini Migkou; Maria Gavriatopoulou; Konstantinos Anargyrou; Peter Hamer; Efstathios Kastritis; Walter Carney; Allan Lipton

doi:10.1016/j.leukres.2009.08.035

High levels of serum TIMP-1 correlate with advanced disease and predict for poor survival in patients with multiple myeloma treated with novel agents

Evangelos Terpos, Meletios A. Dimopoulos, Vikas Shrivastava, Kim Leitzel, Dimitrios Christoulas, Magdalini Migkou, Maria Gavriatopoulou, Konstantinos Anargyrou, Peter Hamer, Efstathios Kastritis, Walter Carney, Allan Lipton

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Tissue inhibitor of metalloproteinase-1 (TIMP-1) was evaluated in the pre-treatment serum of 55 newly diagnosed patients with symptomatic myeloma. TIMP-1 was elevated in 47% of patients and correlated with lytic bone disease and increased bone resorption. Importantly, TIMP-1 correlated with ISS stage (p=0.005) and was an independent prognostic covariate for survival [HR: 1.003 (1-1.006), p=0.004] in these patients who were all treated with novel agents (bortezomib and/or IMiDs) during their disease course. Our study provides evidence that pre-treatment serum TIMP-1 is associated with advanced myeloma and suggests the further evaluation of this molecule to better determine its prognostic potential in MM.

Original language	English (US)
Pages (from-to)	399-402
Number of pages	4
Journal	Leukemia Research
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.leukres.2009.08.035
State	Published - Mar 2010

All Science Journal Classification (ASJC) codes

Hematology
Oncology
Cancer Research

UN SDGs

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10.1016/j.leukres.2009.08.035

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Terpos, E., Dimopoulos, M. A., Shrivastava, V., Leitzel, K., Christoulas, D., Migkou, M., Gavriatopoulou, M., Anargyrou, K., Hamer, P., Kastritis, E., Carney, W., & Lipton, A. (2010). High levels of serum TIMP-1 correlate with advanced disease and predict for poor survival in patients with multiple myeloma treated with novel agents. Leukemia Research, 34(3), 399-402. https://doi.org/10.1016/j.leukres.2009.08.035

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title = "High levels of serum TIMP-1 correlate with advanced disease and predict for poor survival in patients with multiple myeloma treated with novel agents",

abstract = "Tissue inhibitor of metalloproteinase-1 (TIMP-1) was evaluated in the pre-treatment serum of 55 newly diagnosed patients with symptomatic myeloma. TIMP-1 was elevated in 47% of patients and correlated with lytic bone disease and increased bone resorption. Importantly, TIMP-1 correlated with ISS stage (p=0.005) and was an independent prognostic covariate for survival [HR: 1.003 (1-1.006), p=0.004] in these patients who were all treated with novel agents (bortezomib and/or IMiDs) during their disease course. Our study provides evidence that pre-treatment serum TIMP-1 is associated with advanced myeloma and suggests the further evaluation of this molecule to better determine its prognostic potential in MM.",

author = "Evangelos Terpos and Dimopoulos, {Meletios A.} and Vikas Shrivastava and Kim Leitzel and Dimitrios Christoulas and Magdalini Migkou and Maria Gavriatopoulou and Konstantinos Anargyrou and Peter Hamer and Efstathios Kastritis and Walter Carney and Allan Lipton",

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Terpos, E, Dimopoulos, MA, Shrivastava, V, Leitzel, K, Christoulas, D, Migkou, M, Gavriatopoulou, M, Anargyrou, K, Hamer, P, Kastritis, E, Carney, W & Lipton, A 2010, 'High levels of serum TIMP-1 correlate with advanced disease and predict for poor survival in patients with multiple myeloma treated with novel agents', Leukemia Research, vol. 34, no. 3, pp. 399-402. https://doi.org/10.1016/j.leukres.2009.08.035

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AU - Terpos, Evangelos

AU - Dimopoulos, Meletios A.

AU - Shrivastava, Vikas

AU - Leitzel, Kim

AU - Christoulas, Dimitrios

AU - Migkou, Magdalini

AU - Gavriatopoulou, Maria

AU - Anargyrou, Konstantinos

AU - Hamer, Peter

AU - Kastritis, Efstathios

AU - Carney, Walter

AU - Lipton, Allan

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AB - Tissue inhibitor of metalloproteinase-1 (TIMP-1) was evaluated in the pre-treatment serum of 55 newly diagnosed patients with symptomatic myeloma. TIMP-1 was elevated in 47% of patients and correlated with lytic bone disease and increased bone resorption. Importantly, TIMP-1 correlated with ISS stage (p=0.005) and was an independent prognostic covariate for survival [HR: 1.003 (1-1.006), p=0.004] in these patients who were all treated with novel agents (bortezomib and/or IMiDs) during their disease course. Our study provides evidence that pre-treatment serum TIMP-1 is associated with advanced myeloma and suggests the further evaluation of this molecule to better determine its prognostic potential in MM.

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High levels of serum TIMP-1 correlate with advanced disease and predict for poor survival in patients with multiple myeloma treated with novel agents

Abstract

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