TY - JOUR
T1 - High-performance silicon nanopore hemofiltration membranes
AU - Fissell, William H.
AU - Dubnisheva, Anna
AU - Eldridge, Abigail N.
AU - Fleischman, Aaron J.
AU - Zydney, Andrew L.
AU - Roy, Shuvo
N1 - Funding Information:
This work was supported by grants: 1K08 EB003468 (National Institute of Biomedical Imaging and Bioengineering, NIH), 1 R01 EB008049-01 (National Institute of Biomedical Imaging and Bioengineering, NIH), and W81XWH-05-2-0010 (U.S. Army Medical Research and Materiel Command, DoD).
PY - 2009/1/5
Y1 - 2009/1/5
N2 - Silicon micromachining provides the precise control of nanoscale features that can be fundamentally enabling for miniaturized, implantable medical devices. Concerns have been raised regarding blood biocompatibility of silicon-based materials and their application to hemodialysis and hemofiltration. A high-performance ultrathin hemofiltration membrane with monodisperse slit-shaped pores was fabricated using a sacrificial oxide technique and then surface-modified with poly(ethylene glycol) (PEG). Fluid and macromolecular transport matched model predictions well. Protein adsorption, fouling, and thrombosis were significantly inhibited by the PEG. The membrane retained hydraulic permeability and molecular selectivity during a 90-h hemofiltration experiment with anticoagulated bovine whole blood. This is the first report of successful prolonged hemofiltration with a silicon nanopore membrane. The results demonstrate feasibility of renal replacement devices based on these membranes and materials.
AB - Silicon micromachining provides the precise control of nanoscale features that can be fundamentally enabling for miniaturized, implantable medical devices. Concerns have been raised regarding blood biocompatibility of silicon-based materials and their application to hemodialysis and hemofiltration. A high-performance ultrathin hemofiltration membrane with monodisperse slit-shaped pores was fabricated using a sacrificial oxide technique and then surface-modified with poly(ethylene glycol) (PEG). Fluid and macromolecular transport matched model predictions well. Protein adsorption, fouling, and thrombosis were significantly inhibited by the PEG. The membrane retained hydraulic permeability and molecular selectivity during a 90-h hemofiltration experiment with anticoagulated bovine whole blood. This is the first report of successful prolonged hemofiltration with a silicon nanopore membrane. The results demonstrate feasibility of renal replacement devices based on these membranes and materials.
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U2 - 10.1016/j.memsci.2008.09.039
DO - 10.1016/j.memsci.2008.09.039
M3 - Article
C2 - 20054402
AN - SCOPUS:56649106448
SN - 0376-7388
VL - 326
SP - 58
EP - 63
JO - Journal of Membrane Science
JF - Journal of Membrane Science
IS - 1
ER -