High-power acoustic insult to cells as studied by acoustic microscopy

C. Miyasaka, R. Halter, B. R. Tittmann, W. Hymer, N. Nicholas

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


A plurality of articles discussing combined effects of acoustic high-pressure and heat caused by acoustic vibration on biological tissues and cells has been introduced. Herein, we contribute the first article describing the use of a blunt impact caused by high-power ultrasonic pulses for insulting living human skin cells, wherein the impact does not generate heat. The pulses were generated by an apparatus comprising a liquid horn (i.e., water filled horn) including a concave transducer, an apparatus comprising a solid horn (i.e., aluminum waveguide horn) including a disc transducer, and a laser induced ultrasonic shock wave system, wherein the pressures caused by the pulses were measured by a hydrophone, and wherein temperature was monitored by thermocouples. Phenomena indicating cellular insult and injury (e.g., shrinkage or lift-off) were clearly visualized with scanning acoustic microscopy with frequency at 1.0 GHz.

Original languageEnglish (US)
Pages (from-to)1273-1276
Number of pages4
JournalProceedings of the IEEE Ultrasonics Symposium
StatePublished - 2001
Event2001 Ultrasonics Symposium - Atlanta, GA, United States
Duration: Oct 6 2001Oct 10 2001

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics


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