High-resolution MR imaging of the rat spinal cord in vivo in a wide-bore magnet at 17.6 Tesla

V. C. Behr; T. Weber; T. Neuberger; M. Vroemen; N. Weidner; U. Bogdahn; A. Haase; P. M. Jakob; C. Faber

doi:10.1007/s10334-004-0057-5

High-resolution MR imaging of the rat spinal cord in vivo in a wide-bore magnet at 17.6 Tesla

V. C. Behr, T. Weber, T. Neuberger, M. Vroemen, N. Weidner, U. Bogdahn, A. Haase, P. M. Jakob, C. Faber

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The objective was to demonstrate the feasibility and to evaluate the performance of high-resolution in vivo magnetic resonance (MR) imaging of the rat spinal cord in a 17.6-T vertical wide-bore magnet. A probehead consisting of a surface coil that offers enlarged sample volume suitable for rats up to a weight of 220 g was designed. ECG triggered and respiratory-gated gradient echo experiments were performed on a Bruker Avance 750 wide-bore spectrometer for high-resolution imaging. With T₂* values between 5 and 20 ms, good image contrast could be obtained using short echo times, which also minimizes motion artifacts. Anatomy of healthy spinal cords and pathomorphological changes in traumatically injured rat spinal cord in vivo could be visualized with microscopic detail. It was demonstrated that imaging of the rat spinal cord in vivo using a vertical wide-bore high-magnetic-field system is feasible. The potential to obtain high-resolution images in short scan times renders high-field imaging a powerful diagnostic tool.

Original language	English (US)
Pages (from-to)	353-358
Number of pages	6
Journal	Magnetic Resonance Materials in Physics, Biology and Medicine
Volume	17
Issue number	3-6
DOIs	https://doi.org/10.1007/s10334-004-0057-5
State	Published - Dec 2004

All Science Journal Classification (ASJC) codes

Biophysics
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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title = "High-resolution MR imaging of the rat spinal cord in vivo in a wide-bore magnet at 17.6 Tesla",

abstract = "The objective was to demonstrate the feasibility and to evaluate the performance of high-resolution in vivo magnetic resonance (MR) imaging of the rat spinal cord in a 17.6-T vertical wide-bore magnet. A probehead consisting of a surface coil that offers enlarged sample volume suitable for rats up to a weight of 220 g was designed. ECG triggered and respiratory-gated gradient echo experiments were performed on a Bruker Avance 750 wide-bore spectrometer for high-resolution imaging. With T2* values between 5 and 20 ms, good image contrast could be obtained using short echo times, which also minimizes motion artifacts. Anatomy of healthy spinal cords and pathomorphological changes in traumatically injured rat spinal cord in vivo could be visualized with microscopic detail. It was demonstrated that imaging of the rat spinal cord in vivo using a vertical wide-bore high-magnetic-field system is feasible. The potential to obtain high-resolution images in short scan times renders high-field imaging a powerful diagnostic tool.",

author = "Behr, {V. C.} and T. Weber and T. Neuberger and M. Vroemen and N. Weidner and U. Bogdahn and A. Haase and Jakob, {P. M.} and C. Faber",

note = "Funding Information: Acknowledgements We would like to acknowledge Sebastian Aus-senhofer for his expert technical assistance, Ines Wieland for help with building the resonator, and Vikas Gulani for comments on the manuscript. This work was funded by the “Deutsche Forschungs-gemeinschaft (DFG)” under project number “HA 1232/13”.",

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doi = "10.1007/s10334-004-0057-5",

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AU - Vroemen, M.

AU - Weidner, N.

AU - Bogdahn, U.

AU - Haase, A.

AU - Jakob, P. M.

AU - Faber, C.

N1 - Funding Information: Acknowledgements We would like to acknowledge Sebastian Aus-senhofer for his expert technical assistance, Ines Wieland for help with building the resonator, and Vikas Gulani for comments on the manuscript. This work was funded by the “Deutsche Forschungs-gemeinschaft (DFG)” under project number “HA 1232/13”.

PY - 2004/12

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N2 - The objective was to demonstrate the feasibility and to evaluate the performance of high-resolution in vivo magnetic resonance (MR) imaging of the rat spinal cord in a 17.6-T vertical wide-bore magnet. A probehead consisting of a surface coil that offers enlarged sample volume suitable for rats up to a weight of 220 g was designed. ECG triggered and respiratory-gated gradient echo experiments were performed on a Bruker Avance 750 wide-bore spectrometer for high-resolution imaging. With T2* values between 5 and 20 ms, good image contrast could be obtained using short echo times, which also minimizes motion artifacts. Anatomy of healthy spinal cords and pathomorphological changes in traumatically injured rat spinal cord in vivo could be visualized with microscopic detail. It was demonstrated that imaging of the rat spinal cord in vivo using a vertical wide-bore high-magnetic-field system is feasible. The potential to obtain high-resolution images in short scan times renders high-field imaging a powerful diagnostic tool.

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High-resolution MR imaging of the rat spinal cord in vivo in a wide-bore magnet at 17.6 Tesla

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