Hippocampal changes in febrile infection-related epilepsy syndrome (FIRES)

Amit Agarwal, Shyamsunder Sabat, Krishnamurthy Thamburaj, Sangam Kanekar

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Febrile seizures are the most common seizure disorder in childhood, associated with a significant rise in body temperature. However, post-infectious refractory afebrile form of seizures in previously healthy children is being increasingly recognized in around the world, which evolves into a chronic refractory form of epilepsy. The term ‘Febrile infection-related epilepsy syndrome’ (FIRES) has been proposed for these conditions and represents a refractory severe post-infectious epileptic condition in previously normal children. Case Report: We report the initial and follow-up MR imaging findings in a 5year-old with refractory epilepsy post-febrile seizures. Conclusions: In summary, acute post-infectious seizures are increasingly being recognized across the globe with the newly coined term ‘Febrile infection-related epilepsy syndrome’(FIRES) for this group of immune-mediated epileptic encephalopathy in previously healthy children. This has three phases: episode of simple febrile infection, followed by acute refractory seizures and lastly the chronic phase of neuropsychological impairments and seizures.

Original languageEnglish (US)
Pages (from-to)391-394
Number of pages4
JournalPolish Journal of Radiology
Issue number1
StatePublished - Aug 17 2015

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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