TY - JOUR
T1 - Histidine dose-response effects on lactational performance and plasma amino acid concentrations in lactating dairy cows
T2 - 2. Metabolizable protein-deficient diet
AU - Räisänen, S. E.
AU - Lage, C. F.A.
AU - Fetter, M. E.
AU - Melgar, A.
AU - Pelaez, A. M.
AU - Stefenoni, H. A.
AU - Wasson, D. E.
AU - Cueva, S. F.
AU - Zhu, X.
AU - Miura, M.
AU - Hristov, A. N.
N1 - Funding Information:
This work was supported by the USDA National Institute of Food and Agriculture (Washington, DC) Federal Appropriations under project number PEN04539 and accession number 1000803. The authors thank Ajinomoto Co. Inc. (Tokyo, Japan) for providing the experimental RP-His product (AjiPro-L), and for AA analysis of plasma samples, and Evonik Nutrition and Care GmbH (Hanau, Germany) for supplying Mepron. We also thank Papillon Agricultural Company LLC (Easton, MD) for providing hydrolyzed feather meal for the experiment. The authors thank Delaney Snider, The Pennsylvania State University (University Park) for performing various laboratory analyses and the management and staff at The Pennsylvania State University Dairy Research and Teaching Center for their help and care of the experimental cows. The authors have not stated any conflicts of interest.
Publisher Copyright:
© 2021 American Dairy Science Association
PY - 2021/9
Y1 - 2021/9
N2 - The objective of this experiment was to determine the effect of increasing digestible His (dHis) levels with a rumen-protected (RP) His product on milk production, milk composition, and plasma AA concentrations in lactating dairy cows fed a metabolizable protein (MP)-deficient diet, according to the National Research Council dairy model from 2001. The companion paper presents results on the effect of increasing dHis dose with a MP-adequate basal diet. Twenty Holstein cows, of which 8 were rumen-cannulated, were used in a replicated 4 × 4 Latin square design experiment with four 28-d periods. Treatments were a control diet supplying 1.8% dHis of MP or 37 g/d (dHis1.8) and the control diet supplemented RP-His to provide 2.2, 2.6, or 3.0%, dHis of MP, or 53, 63, and 74 g/d (dHis2.2, dHis2.6, and dHis3.0, respectively). Histidine dose did not affect dry matter intake, but milk yield increased quadratically and energy-corrected milk yield increased linearly with increasing dHis dose. Histidine dose had a quadratic effect on milk fat concentration but did not affect milk fat yield. Lactose concentration decreased linearly, whereas lactose yield increased linearly with increasing dHis dose. There was a tendency for a linear increase in milk true protein concentration, and milk true protein yield increased linearly with dHis dose. Further, plasma His concentration increased linearly with increasing dHis dose and calculated apparent efficiency of His utilization decreased quadratically with increasing dHis supply. Histidine had minor or no effects on rumen fermentation. In the conditions of this experiment, RP-His supplementation of an MP-deficient corn silage-based diet increased milk yield linearly up to a dHis supply of 63 g/d (or 2.6% dHis of MP) and increased feed efficiency, energy-corrected milk yield and milk true protein yield linearly up to a dHis supply of 74 g/d (or 3.0% dHis of MP) in lactating dairy cows.
AB - The objective of this experiment was to determine the effect of increasing digestible His (dHis) levels with a rumen-protected (RP) His product on milk production, milk composition, and plasma AA concentrations in lactating dairy cows fed a metabolizable protein (MP)-deficient diet, according to the National Research Council dairy model from 2001. The companion paper presents results on the effect of increasing dHis dose with a MP-adequate basal diet. Twenty Holstein cows, of which 8 were rumen-cannulated, were used in a replicated 4 × 4 Latin square design experiment with four 28-d periods. Treatments were a control diet supplying 1.8% dHis of MP or 37 g/d (dHis1.8) and the control diet supplemented RP-His to provide 2.2, 2.6, or 3.0%, dHis of MP, or 53, 63, and 74 g/d (dHis2.2, dHis2.6, and dHis3.0, respectively). Histidine dose did not affect dry matter intake, but milk yield increased quadratically and energy-corrected milk yield increased linearly with increasing dHis dose. Histidine dose had a quadratic effect on milk fat concentration but did not affect milk fat yield. Lactose concentration decreased linearly, whereas lactose yield increased linearly with increasing dHis dose. There was a tendency for a linear increase in milk true protein concentration, and milk true protein yield increased linearly with dHis dose. Further, plasma His concentration increased linearly with increasing dHis dose and calculated apparent efficiency of His utilization decreased quadratically with increasing dHis supply. Histidine had minor or no effects on rumen fermentation. In the conditions of this experiment, RP-His supplementation of an MP-deficient corn silage-based diet increased milk yield linearly up to a dHis supply of 63 g/d (or 2.6% dHis of MP) and increased feed efficiency, energy-corrected milk yield and milk true protein yield linearly up to a dHis supply of 74 g/d (or 3.0% dHis of MP) in lactating dairy cows.
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U2 - 10.3168/jds.2021-20189
DO - 10.3168/jds.2021-20189
M3 - Article
C2 - 34099295
AN - SCOPUS:85108216957
SN - 0022-0302
VL - 104
SP - 9917
EP - 9930
JO - Journal of dairy science
JF - Journal of dairy science
IS - 9
ER -