Histiocytic sarcoma with two immunohistopathologically distinct populations

Kanako Wakahashi; Manabu Shimoyama; Yoshio Katayama; Kentaro Minagawa; Kenji Yoshida; Ryohei Sasaki; Shunji Nakayama; Hiroshi Yokozaki; Emmy Yanagita; Tomoo Itoh; Yoshitake Hayashi; Toshimitsu Matsui

doi:10.1007/s12185-010-0699-1

Histiocytic sarcoma with two immunohistopathologically distinct populations

Kanako Wakahashi, Manabu Shimoyama, Yoshio Katayama, Kentaro Minagawa, Kenji Yoshida, Ryohei Sasaki, Shunji Nakayama, Hiroshi Yokozaki, Emmy Yanagita, Tomoo Itoh, Yoshitake Hayashi, Toshimitsu Matsui

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Abstract

This report is a case of histiocytic sarcoma (HS), in which tumor cells consist of two immunohistopathologically distinct populations (A) oval CD68+lysozyme+CD163- cells and (B) abundant cytoplasm or spindle-shaped CD68+lysozyme-CD163+ cells. Cervical lymph node was infiltrated mainly by population (A), where chemotherapy was quite effective. On the other hand, vast majority of infiltrated tumor cells in the hilar lymph node belonged to population (B), in which the cells were resistant to chemo-radiotherapy. Considering the poor prognosis of HS, the expression of CD163 could be a marker for resistance to chemo-radiotherapy. It is also notable that CD163-negative stage of HS may exist and still be reactive for the treatment.

Original language	English (US)
Pages (from-to)	642-646
Number of pages	5
Journal	International journal of hematology
Volume	92
Issue number	4
DOIs	https://doi.org/10.1007/s12185-010-0699-1
State	Published - Nov 2010

All Science Journal Classification (ASJC) codes

Hematology

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10.1007/s12185-010-0699-1

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@article{19351910ea6845db89bb4499e920d849,

title = "Histiocytic sarcoma with two immunohistopathologically distinct populations",

abstract = "This report is a case of histiocytic sarcoma (HS), in which tumor cells consist of two immunohistopathologically distinct populations (A) oval CD68+lysozyme+CD163- cells and (B) abundant cytoplasm or spindle-shaped CD68+lysozyme-CD163+ cells. Cervical lymph node was infiltrated mainly by population (A), where chemotherapy was quite effective. On the other hand, vast majority of infiltrated tumor cells in the hilar lymph node belonged to population (B), in which the cells were resistant to chemo-radiotherapy. Considering the poor prognosis of HS, the expression of CD163 could be a marker for resistance to chemo-radiotherapy. It is also notable that CD163-negative stage of HS may exist and still be reactive for the treatment.",

author = "Kanako Wakahashi and Manabu Shimoyama and Yoshio Katayama and Kentaro Minagawa and Kenji Yoshida and Ryohei Sasaki and Shunji Nakayama and Hiroshi Yokozaki and Emmy Yanagita and Tomoo Itoh and Yoshitake Hayashi and Toshimitsu Matsui",

year = "2010",

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doi = "10.1007/s12185-010-0699-1",

language = "English (US)",

volume = "92",

pages = "642--646",

journal = "International journal of hematology",

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TY - JOUR

T1 - Histiocytic sarcoma with two immunohistopathologically distinct populations

AU - Wakahashi, Kanako

AU - Shimoyama, Manabu

AU - Katayama, Yoshio

AU - Minagawa, Kentaro

AU - Yoshida, Kenji

AU - Sasaki, Ryohei

AU - Nakayama, Shunji

AU - Yokozaki, Hiroshi

AU - Yanagita, Emmy

AU - Itoh, Tomoo

AU - Hayashi, Yoshitake

AU - Matsui, Toshimitsu

PY - 2010/11

Y1 - 2010/11

N2 - This report is a case of histiocytic sarcoma (HS), in which tumor cells consist of two immunohistopathologically distinct populations (A) oval CD68+lysozyme+CD163- cells and (B) abundant cytoplasm or spindle-shaped CD68+lysozyme-CD163+ cells. Cervical lymph node was infiltrated mainly by population (A), where chemotherapy was quite effective. On the other hand, vast majority of infiltrated tumor cells in the hilar lymph node belonged to population (B), in which the cells were resistant to chemo-radiotherapy. Considering the poor prognosis of HS, the expression of CD163 could be a marker for resistance to chemo-radiotherapy. It is also notable that CD163-negative stage of HS may exist and still be reactive for the treatment.

AB - This report is a case of histiocytic sarcoma (HS), in which tumor cells consist of two immunohistopathologically distinct populations (A) oval CD68+lysozyme+CD163- cells and (B) abundant cytoplasm or spindle-shaped CD68+lysozyme-CD163+ cells. Cervical lymph node was infiltrated mainly by population (A), where chemotherapy was quite effective. On the other hand, vast majority of infiltrated tumor cells in the hilar lymph node belonged to population (B), in which the cells were resistant to chemo-radiotherapy. Considering the poor prognosis of HS, the expression of CD163 could be a marker for resistance to chemo-radiotherapy. It is also notable that CD163-negative stage of HS may exist and still be reactive for the treatment.

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VL - 92

SP - 642

EP - 646

JO - International journal of hematology

JF - International journal of hematology

IS - 4

ER -

Histiocytic sarcoma with two immunohistopathologically distinct populations

Abstract

All Science Journal Classification (ASJC) codes

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