Histiocytic typhlocolitis in two colony Beagle dogs

Francisco R. Carvallo; Roy Kerlin; Claudine Fredette; Harshan Pisharath; Chitrita DebRoy; Subhashinie Kariyawasam; Ingrid D. Pardo

doi:10.1016/j.etp.2014.10.004

Histiocytic typhlocolitis in two colony Beagle dogs

Francisco R. Carvallo, Roy Kerlin, Claudine Fredette, Harshan Pisharath, Chitrita DebRoy, Subhashinie Kariyawasam, Ingrid D. Pardo

Veterinary and Biomedical Sciences

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10 Scopus citations

Abstract

Two young female Beagle dogs in a laboratory colony with clinical signs of loose stools and fecal blood were confirmed to have histiocytic ulcerative colitis by histologic evaluation. This syndrome is well recognized in other dog breeds such as Boxers and related French Bulldogs, Mastiffs, Alaskan malamutes and Doberman Pinschers. Formalin-fixed paraffin sections of large intestine from one dog demonstrated the presence of Escherichia coli strain LF82 by immunohistochemistry and 16S ribosomal RNA gene sequencing. E coli strain LF82 has been implicated in the pathogenesis of Crohn's disease and similar bacteria have been cultured from cases of histiocytic ulcerative colitis in Boxer dogs. Spontaneous histiocytic ulcerative colitis must be differentiated from test article-related findings in nonclinical toxicity studies in Beagle dogs.

Original language	English (US)
Pages (from-to)	219-221
Number of pages	3
Journal	Experimental and Toxicologic Pathology
Volume	67
Issue number	2
DOIs	https://doi.org/10.1016/j.etp.2014.10.004
State	Published - Feb 1 2015

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Toxicology
Cell Biology

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10.1016/j.etp.2014.10.004

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title = "Histiocytic typhlocolitis in two colony Beagle dogs",

abstract = "Two young female Beagle dogs in a laboratory colony with clinical signs of loose stools and fecal blood were confirmed to have histiocytic ulcerative colitis by histologic evaluation. This syndrome is well recognized in other dog breeds such as Boxers and related French Bulldogs, Mastiffs, Alaskan malamutes and Doberman Pinschers. Formalin-fixed paraffin sections of large intestine from one dog demonstrated the presence of Escherichia coli strain LF82 by immunohistochemistry and 16S ribosomal RNA gene sequencing. E coli strain LF82 has been implicated in the pathogenesis of Crohn's disease and similar bacteria have been cultured from cases of histiocytic ulcerative colitis in Boxer dogs. Spontaneous histiocytic ulcerative colitis must be differentiated from test article-related findings in nonclinical toxicity studies in Beagle dogs.",

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AU - Carvallo, Francisco R.

AU - Kerlin, Roy

AU - Fredette, Claudine

AU - Pisharath, Harshan

AU - DebRoy, Chitrita

AU - Kariyawasam, Subhashinie

AU - Pardo, Ingrid D.

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AB - Two young female Beagle dogs in a laboratory colony with clinical signs of loose stools and fecal blood were confirmed to have histiocytic ulcerative colitis by histologic evaluation. This syndrome is well recognized in other dog breeds such as Boxers and related French Bulldogs, Mastiffs, Alaskan malamutes and Doberman Pinschers. Formalin-fixed paraffin sections of large intestine from one dog demonstrated the presence of Escherichia coli strain LF82 by immunohistochemistry and 16S ribosomal RNA gene sequencing. E coli strain LF82 has been implicated in the pathogenesis of Crohn's disease and similar bacteria have been cultured from cases of histiocytic ulcerative colitis in Boxer dogs. Spontaneous histiocytic ulcerative colitis must be differentiated from test article-related findings in nonclinical toxicity studies in Beagle dogs.

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Histiocytic typhlocolitis in two colony Beagle dogs

Abstract

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