Histiocytic typhlocolitis in two colony Beagle dogs

Francisco R. Carvallo, Roy Kerlin, Claudine Fredette, Harshan Pisharath, Chitrita DebRoy, Subhashinie Kariyawasam, Ingrid D. Pardo

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Two young female Beagle dogs in a laboratory colony with clinical signs of loose stools and fecal blood were confirmed to have histiocytic ulcerative colitis by histologic evaluation. This syndrome is well recognized in other dog breeds such as Boxers and related French Bulldogs, Mastiffs, Alaskan malamutes and Doberman Pinschers. Formalin-fixed paraffin sections of large intestine from one dog demonstrated the presence of Escherichia coli strain LF82 by immunohistochemistry and 16S ribosomal RNA gene sequencing. E coli strain LF82 has been implicated in the pathogenesis of Crohn's disease and similar bacteria have been cultured from cases of histiocytic ulcerative colitis in Boxer dogs. Spontaneous histiocytic ulcerative colitis must be differentiated from test article-related findings in nonclinical toxicity studies in Beagle dogs.

Original languageEnglish (US)
Pages (from-to)219-221
Number of pages3
JournalExperimental and Toxicologic Pathology
Issue number2
StatePublished - Feb 1 2015

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Cell Biology


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