Histocompatibility-2 system in wild mice. VI. Histogenetic analysis of sixteen B10.W congenic lines

J. Klein, Z. Zaleska-Rutczynska

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Sixteen B10.W congenic lines carrying wild derived H-2 haplotypes on C57BL/10Sn or B10 background were typed by the allogeneic cell-mediated lymphocytotoxicity (CML) assay; in addition, selected lines were also typed by the TNP-CML assay and by skin grafting. The analysis revealed similarity or identity of 2 strain pairs: SNA57 (H-2w21) seems to carry a similar haplotype as B10.SM (H-2v), and STA10 and STA12 seem to share the same H-2K and H-2D alleles. All other B10.W strains were different from each other and from B10 congenic lines carrying inbred-derived H-2 haplotypes. These results agree with the results of the serologic typing with 2 exceptions: the KPA42, KPA132, and SNA57 lines, which were serologically indistinguishable from each other and from B10.SM, were distinguished by histogenetic typing. The presence among wild mice of a haplotype (H-2w21) that appears to be very similar to a haplotype (H-2v) carried by an inbred strain (B10.SM) has some interesting implications for considerations of H-2 gene mutability. The finding that haplotypes derived from different localities are different provides further evidence that the H-2 polymorphism is extensive, indeed.

Original languageEnglish (US)
Pages (from-to)1912-1915
Number of pages4
JournalJournal of Immunology
Issue number6
StatePublished - 1977

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology


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