Histopathology of argon laser peripheral iridoplasty

Joseph Sassani, R. Ritch, S. McCormick, J. M. Liebmann, R. C. Eagle, K. Lavery, H. R. Koster

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


We report the light and electron microscopic findings from two eyes treated with argon laser peripheral iridoplasty (ALPI) for bilateral angle- closure glaucoma. The patient, a 45-year-old man, died from complications of acquired immunodeficiency syndrome 16 days following ALPI. Ocular pathologic findings included contraction furrow formation and proliferation of fibroblast-like cells, accompanied by collagen deposition on the iris surface, denaturation of stromal collagen, and coagulative necrosis of blood vessels within the anterior two thirds of the iris stroma. These findings suggest that heat shrinkage of collagen may be responsible for the short- term response to ALPI, and that contraction of the fibroblastic membrane may be responsible for its long-term effects. Additionally, the presence of coagulative necrosis of iris blood vessels suggests that overtreatment may result in iris necrosis. To our knowledge this is the first report of the histopathology of ALPI.

Original languageEnglish (US)
Pages (from-to)740-745
Number of pages6
JournalOphthalmic Surgery
Issue number11
StatePublished - Jan 1 1993

All Science Journal Classification (ASJC) codes

  • Ophthalmology


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