@article{82040c44a5e745a99013dfc9a1d76024,
title = "HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells",
abstract = "Infection with human immunodeficiency virus 1 (HIV-1) results in the dissemination of virus to gut-associated lymphoid tissue. Subsequently, HIV-1 mediates massive depletion of gut CD4+ T cells, which contributes to HIV-1-induced immune dysfunction. The migration of lymphocytes to gut-associated lymphoid tissue is mediated by integrin α4β7. We demonstrate here that the HIV-1 envelope protein gp120 bound to an activated form of α4β7. This interaction was mediated by a tripeptide in the V2 loop of gp120, a peptide motif that mimics structures presented by the natural ligands of alpha;4 β7. On CD4+ T cells, engagement of alpha;4 β7 by gp120 resulted in rapid activation of LFA-1, the central integrin involved in the establishment of virological synapses, which facilitate efficient cell-to-cell spreading of HIV-1.",
author = "James Arthos and Claudia Cicala and Elena Martinelli and Katilyn Macleod and {Van Ryk}, Donald and Danlan Wei and Zhen Xiao and Veenstra, {Timothy D.} and Conrad, {Thomas P.} and Lempicki, {Richard A.} and Sherry McLaughlin and Massimiliano Pascuccio and Ravindra Gopaul and Jonathan McNally and Cruz, {Catherine C.} and Nina Censoplano and Eva Chung and Reitano, {Kristin N.} and Shyam Kottilil and Goode, {Diana J.} and Fauci, {Anthony S.}",
note = "Funding Information: We thank S. Shaw, G. Snyder, T.-W. Chun, A. Kinter and S. Moir for discussions; J.I. Mullins for providing the AN1 coding sequence; J. Weddle for figure preparation; and the National Institutes of Health AIDS Research and Reference Reagent Program for many reagents. Act-1 was provided by S. Shaw (National Cancer Institute), and NL43-SF162 was provided by R.L. Willey (National Institute of Allergy and Infectious Diseases). Supported by the National Institutes of Health (AI058894 and AI047734 to S.M.; and the Intramural Research Program).",
year = "2008",
month = mar,
doi = "10.1038/ni1566",
language = "English (US)",
volume = "9",
pages = "301--309",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Research",
number = "3",
}