TY - JOUR
T1 - HLA-class II antigen expression in human heart-lung allografts
AU - Yousem, Samuel A.
AU - Curley, Joseph M.
AU - Dauber, James
AU - Paradis, Irvin
AU - Rabinowich, Hanna
AU - Zeevi, Adriana
AU - Duquesnoy, Rene
AU - Dowling, Robert
AU - Zenati, Marco
AU - Hardesty, Robert
AU - Griffith, Bartley P.
PY - 1990/5
Y1 - 1990/5
N2 - Long-term survival in heart-lung transplantation has ben hindered by the development of bronchiolitis obliterans (OB), which is believed to be a manifestation of chronic rejection of the lung. Since HLA-class II antigens are involved in the rejection response, the distribution of the class II products HLA-DR, HLA-DQ, and HLA-DP were studied in normal lung, and in transplanted lung with and without OB, utilizing frozen- section immunohistochemical techniques. All three allelic products are usually expressed on the epithelial, endothelial, and mesenchymal components of the lung. Sequential transbronchial biopsies from 4 recipients before and concurrent with the diagnosis of OB were stained with serial dilutions of monoclonal antibodies to assess the level of expression of the above class II products. Increased levels of HLA-DR and HLA-DP antigens may be seen on the bronchial and bronchiolar epithelium during OB, but the changes are subtle and complicated by many other variables. Additional studies are needed to confirm these preliminary results.
AB - Long-term survival in heart-lung transplantation has ben hindered by the development of bronchiolitis obliterans (OB), which is believed to be a manifestation of chronic rejection of the lung. Since HLA-class II antigens are involved in the rejection response, the distribution of the class II products HLA-DR, HLA-DQ, and HLA-DP were studied in normal lung, and in transplanted lung with and without OB, utilizing frozen- section immunohistochemical techniques. All three allelic products are usually expressed on the epithelial, endothelial, and mesenchymal components of the lung. Sequential transbronchial biopsies from 4 recipients before and concurrent with the diagnosis of OB were stained with serial dilutions of monoclonal antibodies to assess the level of expression of the above class II products. Increased levels of HLA-DR and HLA-DP antigens may be seen on the bronchial and bronchiolar epithelium during OB, but the changes are subtle and complicated by many other variables. Additional studies are needed to confirm these preliminary results.
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U2 - 10.1097/00007890-199005000-00030
DO - 10.1097/00007890-199005000-00030
M3 - Article
C2 - 2186527
AN - SCOPUS:0025316776
SN - 0041-1337
VL - 49
SP - 991
EP - 995
JO - Transplantation
JF - Transplantation
IS - 5
ER -