HLA–DPB1*0301 is a Major Risk Factor for Rheumatoid Factor–Negative Adult Rheumatoid Arthritis

Xiaojiang Gao; Marcelo Fernandez‐Vina; Nancy J. Olsen; Theodore Pincus; Peter Stastny

doi:10.1002/art.1780341016

HLA–DPB1*0301 is a Major Risk Factor for Rheumatoid Factor–Negative Adult Rheumatoid Arthritis

Xiaojiang Gao
, Marcelo Fernandez‐Vina
, Nancy J. Olsen
, Theodore Pincus
, Peter Stastny

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

HLA–DPB1 alleles were determined using the polymerase chain reaction and allele‐specific oligonucleotide probes in Caucasoid patients with rheumatoid arthritis (RA) and in healthy controls. DPB1*0301 was found to be increased in seronegative patients (50.0% versus 10.8% in controls; relative risk = 8.3, P < 0.0001). With our previous finding that DPB1^*0301 is increased in seronegative children with polyarticularonset arthritis, the results suggest a relationship between this disease and seronegative RA in adults.

Original language	English (US)
Pages (from-to)	1310-1312
Number of pages	3
Journal	Arthritis and Rheumatism
Volume	34
Issue number	10
DOIs	https://doi.org/10.1002/art.1780341016
State	Published - Oct 10 1991

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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10.1002/art.1780341016

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title = "HLA–DPB1*0301 is a Major Risk Factor for Rheumatoid Factor–Negative Adult Rheumatoid Arthritis",

abstract = "HLA–DPB1 alleles were determined using the polymerase chain reaction and allele‐specific oligonucleotide probes in Caucasoid patients with rheumatoid arthritis (RA) and in healthy controls. DPB1*0301 was found to be increased in seronegative patients (50.0\% versus 10.8\% in controls; relative risk = 8.3, P < 0.0001). With our previous finding that DPB1*0301 is increased in seronegative children with polyarticularonset arthritis, the results suggest a relationship between this disease and seronegative RA in adults.",

author = "Xiaojiang Gao and Marcelo Fernandez‐Vina and Olsen, \{Nancy J.\} and Theodore Pincus and Peter Stastny",

year = "1991",

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doi = "10.1002/art.1780341016",

language = "English (US)",

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journal = "Arthritis and Rheumatism",

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T1 - HLA–DPB1*0301 is a Major Risk Factor for Rheumatoid Factor–Negative Adult Rheumatoid Arthritis

AU - Gao, Xiaojiang

AU - Fernandez‐Vina, Marcelo

AU - Olsen, Nancy J.

AU - Pincus, Theodore

AU - Stastny, Peter

PY - 1991/10/10

Y1 - 1991/10/10

N2 - HLA–DPB1 alleles were determined using the polymerase chain reaction and allele‐specific oligonucleotide probes in Caucasoid patients with rheumatoid arthritis (RA) and in healthy controls. DPB1*0301 was found to be increased in seronegative patients (50.0% versus 10.8% in controls; relative risk = 8.3, P < 0.0001). With our previous finding that DPB1*0301 is increased in seronegative children with polyarticularonset arthritis, the results suggest a relationship between this disease and seronegative RA in adults.

AB - HLA–DPB1 alleles were determined using the polymerase chain reaction and allele‐specific oligonucleotide probes in Caucasoid patients with rheumatoid arthritis (RA) and in healthy controls. DPB1*0301 was found to be increased in seronegative patients (50.0% versus 10.8% in controls; relative risk = 8.3, P < 0.0001). With our previous finding that DPB1*0301 is increased in seronegative children with polyarticularonset arthritis, the results suggest a relationship between this disease and seronegative RA in adults.

UR - https://www.scopus.com/pages/publications/0025924936

UR - https://www.scopus.com/pages/publications/0025924936#tab=citedBy

U2 - 10.1002/art.1780341016

DO - 10.1002/art.1780341016

M3 - Article

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AN - SCOPUS:0025924936

SN - 0004-3591

VL - 34

SP - 1310

EP - 1312

JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

IS - 10

ER -

HLA–DPB1*0301 is a Major Risk Factor for Rheumatoid Factor–Negative Adult Rheumatoid Arthritis

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