Homeostatic competition between phasic and tonic inhibition

Xia Wu; Lanting Huang; Zheng Wu; Ce Zhang; Dongyun Jiang; Yuting Bai; Yun Wang; Gong Chen

doi:10.1074/jbc.M113.491464

Homeostatic competition between phasic and tonic inhibition

Xia Wu, Lanting Huang, Zheng Wu, Ce Zhang, Dongyun Jiang, Yuting Bai, Yun Wang, Gong Chen

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Background: Synaptic and extrasynaptic GABA_A receptors mediate phasic and tonic inhibition, respectively. Results: Overexpression of extrasynaptic GABA_A receptors decreases synaptic GABAergic transmission. Conclusion: Synaptic and extrasynaptic GABA_A receptors may have intrinsic competition in single individual neurons. Significance: Phasic and tonic inhibition interacts to maintain homeostasis of total inhibition.

Original language	English (US)
Pages (from-to)	25053-25065
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	288
Issue number	35
DOIs	https://doi.org/10.1074/jbc.M113.491464
State	Published - Aug 30 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.491464

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title = "Homeostatic competition between phasic and tonic inhibition",

abstract = "Background: Synaptic and extrasynaptic GABAA receptors mediate phasic and tonic inhibition, respectively. Results: Overexpression of extrasynaptic GABAA receptors decreases synaptic GABAergic transmission. Conclusion: Synaptic and extrasynaptic GABAA receptors may have intrinsic competition in single individual neurons. Significance: Phasic and tonic inhibition interacts to maintain homeostasis of total inhibition.",

author = "Xia Wu and Lanting Huang and Zheng Wu and Ce Zhang and Dongyun Jiang and Yuting Bai and Yun Wang and Gong Chen",

year = "2013",

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doi = "10.1074/jbc.M113.491464",

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TY - JOUR

T1 - Homeostatic competition between phasic and tonic inhibition

AU - Wu, Xia

AU - Huang, Lanting

AU - Wu, Zheng

AU - Zhang, Ce

AU - Jiang, Dongyun

AU - Bai, Yuting

AU - Wang, Yun

AU - Chen, Gong

PY - 2013/8/30

Y1 - 2013/8/30

N2 - Background: Synaptic and extrasynaptic GABAA receptors mediate phasic and tonic inhibition, respectively. Results: Overexpression of extrasynaptic GABAA receptors decreases synaptic GABAergic transmission. Conclusion: Synaptic and extrasynaptic GABAA receptors may have intrinsic competition in single individual neurons. Significance: Phasic and tonic inhibition interacts to maintain homeostasis of total inhibition.

AB - Background: Synaptic and extrasynaptic GABAA receptors mediate phasic and tonic inhibition, respectively. Results: Overexpression of extrasynaptic GABAA receptors decreases synaptic GABAergic transmission. Conclusion: Synaptic and extrasynaptic GABAA receptors may have intrinsic competition in single individual neurons. Significance: Phasic and tonic inhibition interacts to maintain homeostasis of total inhibition.

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DO - 10.1074/jbc.M113.491464

M3 - Article

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AN - SCOPUS:84883320782

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SP - 25053

EP - 25065

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 35

ER -

Homeostatic competition between phasic and tonic inhibition

Abstract

All Science Journal Classification (ASJC) codes

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