Homology-independent protein engineering

Stefan Lutz, Stephen J. Benkovic

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Is structure, rather than sequence, the key to the successful generation of truly novel proteins? While protein evolution by homologous recombination has become an established tool to explore confined regions in sequence space, the generation of functional hybrid proteins by homology-independent methods further expands the scope of protein engineering.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalCurrent Opinion in Biotechnology
Issue number4
StatePublished - Aug 1 2000

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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