Abstract
Reciprocal radiation bone-marrow chimeras were produced between the standard C57BL/6 (=B6) and the mutant B6.C -H-2ba (=Hz1) strain. When infected with vaccinia virus, these chimeras, as well as an (Hz1 × B6)=→ Hz1 chimera, produced cytotoxic cells that killed vaccinia-infected H-2KkH-2Db target cells but failed to kill virus-infected H-2KbH-2Dd cells. Virus-infected (Hz1 × B6)F1 → B6 chimeras, however, killed both types of target. These experiments demonstrate strict T-cell specificity capable of differentiating between two molecules that apparently differ by a single amino acid substitution.
Original language | English (US) |
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Pages (from-to) | 73-77 |
Number of pages | 5 |
Journal | Immunogenetics |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - Dec 1978 |
All Science Journal Classification (ASJC) codes
- Immunology
- Genetics