How powerful are summary-based methods for identifying expression-trait associations under different genetic architectures?

Keyphrases

• Genetic Architecture 100%
• Transcriptome-wide Association Study 100%
• Genome-wide Association Study 70%
• Gene Expression 30%
• Complex Traits 20%
• Pleiotropy 20%
• Training Set 20%
• Least Absolute Shrinkage and Selection Operator (LASSO) 20%
• Elastic Net 20%
• Expression Quantitative Trait Loci (eQTL) 20%
• High Power 10%
• Complex Disease 10%
• Popular 10%
• Gene Expression Studies 10%
• Moderate Power 10%
• Genetic Model 10%
• Low-to-moderate 10%
• Genetic Background 10%
• Genetic Components 10%
• Disease Impact 10%
• Heritability 10%
• Simulation-based 10%
• Quantitative Trait Loci 10%
• Small-sized 10%
• Regression Coefficient 10%
• Statistical Power 10%
• Relevant Genes 10%
• Bayesian Methods 10%
• Trait Heritability 10%
• Gene Phenotype 10%
• Effective Sample Size 10%
• Training Sample Size 10%
• QTL Analysis 10%
• Functional Variants 10%
• Mendelian Randomization Analysis 10%
• Simulation Scenarios 10%
• Trait Structure 10%
• Per Genes 10%

Biochemistry, Genetics and Molecular Biology

• Genetic Architecture 100%
• Transcriptome 100%
• Genome-Wide Association Study 70%
• Gene Expression 40%
• Pleiotropy 20%
• Sample Size 20%
• Expression Quantitative Trait Loci 20%
• Single Nucleotide Polymorphism 10%
• Genetics 10%
• Genetic Model 10%
• Genetic Background 10%
• Quantitative Trait Locus 10%
• Spike 10%
• Mendelian Randomization 10%