TY - JOUR
T1 - How Saccharomyces responds to nutrients
AU - Zaman, Shadia
AU - Lippman, Soyeon Im
AU - Zhao, Xin
AU - Broach, James R.
PY - 2008
Y1 - 2008
N2 - Yeast cells sense the amount and quality of external nutrients through multiple interconnected signaling networks, which allow them to adjust their metabolism, transcriptional profile and developmental program to adapt readily and appropriately to changing nutritional states. We present our current understanding of the nutritional sensing networks yeast cells rely on for perceiving the nutritional landscape, with particular emphasis on those sensitive to carbon and nitrogen sources. We describe the means by which these networks inform the cell's decision among the different developmental programs available to them - growth, quiescence, filamentous development, or meiosis/sporulation. We conclude that the highly interconnected signaling networks provide the cell with a highly nuanced view of the environment and that the cell can interpret that information through a sophisticated calculus to achieve optimum responses to any nutritional condition.
AB - Yeast cells sense the amount and quality of external nutrients through multiple interconnected signaling networks, which allow them to adjust their metabolism, transcriptional profile and developmental program to adapt readily and appropriately to changing nutritional states. We present our current understanding of the nutritional sensing networks yeast cells rely on for perceiving the nutritional landscape, with particular emphasis on those sensitive to carbon and nitrogen sources. We describe the means by which these networks inform the cell's decision among the different developmental programs available to them - growth, quiescence, filamentous development, or meiosis/sporulation. We conclude that the highly interconnected signaling networks provide the cell with a highly nuanced view of the environment and that the cell can interpret that information through a sophisticated calculus to achieve optimum responses to any nutritional condition.
UR - http://www.scopus.com/inward/record.url?scp=58549084410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58549084410&partnerID=8YFLogxK
U2 - 10.1146/annurev.genet.41.110306.130206
DO - 10.1146/annurev.genet.41.110306.130206
M3 - Review article
C2 - 18303986
AN - SCOPUS:58549084410
SN - 0066-4197
VL - 42
SP - 27
EP - 81
JO - Annual review of genetics
JF - Annual review of genetics
ER -