How Should Beta-Blockers Be Used Perioperatively?

Adam Y. Adenwala, William J. Vernick

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Perioperative beta-blockade (PBB) has been advocated for the reduction of cardiac risk for noncardiac surgery, primarily through prevention of major adverse cardiac events (MACE). Nevertheless, the data and recommendations supporting PBB have been both changing and conflicting. Early interest in using beta-blockers to protect against perioperative cardiovascular complications was supported by a small number of randomized controlled trials (RCTs) and reviews, and beta-blockers were quickly adopted because their perceived benefit was considered large with few documented adverse effects. More recent data however, suggest that PBB may carry significantly increased risk for perioperative morbidity and mortality for many patients, particularly through increased risk for stroke and hypotension. This chapter aims to provide a review of the development of literature surrounding PBB, discuss the uncertainties surrounding PBB, and review the American and European guidelines surrounding use of beta-blockers during the perioperative period. A focus of this chapter is on recent updates in the literature and recommendations over the past decade.

Original languageEnglish (US)
Title of host publicationEvidence-Based Practice of Anesthesiology
PublisherElsevier
Pages109-117
Number of pages9
ISBN (Electronic)9780323778466
ISBN (Print)9780323778473
DOIs
StatePublished - Jan 1 2022

All Science Journal Classification (ASJC) codes

  • General Medicine

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