Hox cluster genomics in the horn shark, Heterodontus francisci

Chang Bae Kim, Chris Amemiya, Wendy Bailey, Kazuhiko Kawasaki, Jason Mezey, Webb Miller, Shinsei Minoshima, Nobuyoshi Shimizu, Günter Wagner, Frank Ruddle

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


Reconstructing the evolutionary history of Hox cluster origins will lead to insights into the developmental and evolutionary significance of Hox gene clusters in vertebrate phylogeny and to their role in the origins of various vertebrate body plans. We have isolated two Hox clusters from the horn shark, Heterodontus francisci. These have been sequenced and compared with one another and with other chordate Hox clusters. The results show that one of the horn shark clusters (HoxM) is orthologous to the mammalian HoxA cluster and shows a structural similarity to the amphioxus cluster, whereas the other shark cluster (HoxN) is orthologous to the mammalian HoxD cluster based on cluster organization and a comparison with noncoding and Hox genecoding sequences. The persistence of an identifiable HoxA cluster over an 800- million-year divergence time demonstrates that the Hox gene clusters are highly integrated and structured genetic entities. The data presented herein identify many noncoding sequence motifs conserved over 800 million years that may function as genetic control motifs essential to the developmental process.

Original languageEnglish (US)
Pages (from-to)1655-1660
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number4
StatePublished - Feb 15 2000

All Science Journal Classification (ASJC) codes

  • General


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