@article{ccd16bcbc4bf4ba9b0e109b84a2a4155,
title = "Human coronavirus NL63 is not detected in the respiratory tracts of children with acute Kawasaki disease",
abstract = "Kawasaki disease (KD) is a self-limited, systemic vasculitis of children for which an infectious trigger is suspected. Recently, an association between KD and human coronavirus (HCoV)-New Haven (NH) was reported, on the basis of polymerase chain reaction (PCR) with primers that also amplified HCoV-NL63. We investigated the possible association between these HCoVs in the respiratory tract and KD by reverse-transcriptase (RT) PCR and viral culture in a geographically and ethnically diverse population. Only 1 (2\%) of 48 patients with acute KD was positive by RT-PCR for HCoV-NL63/NH in a nasopharyngeal swab. These data do not support an association between these HCoVs and KD.",
author = "Chisato Shimizu and Hiroko Shike and Baker, \{Susan C.\} and Francesca Garcia and \{Van Der Hoek\}, Lia and Kuijpers, \{Taco W.\} and Reed, \{Sharon L.\} and Rowley, \{Anne H.\} and Shulman, \{Stanford T.\} and Talbot, \{Helen K.B.\} and Williams, \{John V.\} and Burns, \{Jane C.\}",
note = "Funding Information: Received 6 May 2005; accepted 21 June 2005; electronically published 17 October 2005. Presented in part: 8th International Kawasaki Disease Symposium, San Diego, 17–20 February 2005; annual meeting of the Pediatric Academic Societies, Washington, DC, 14–17 May 2005. Potential conflicts of interest: none reported. Financial support: National Institutes of Health (grants RO1 HL69413 to J.C.B., AI45798 to S.C.B., and HL63771 and HL67011 to A.H.R.). Reprints or correspondence: Dr. Jane C. Burns, UCSD School of Medicine, Dept. of Pediatrics/0830, 9500 Gilman Dr., La Jolla, CA 92093-0830 (
[email protected]).",
year = "2005",
month = nov,
day = "15",
doi = "10.1086/497170",
language = "English (US)",
volume = "192",
pages = "1767--1771",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "10",
}