Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

David J. Vandenbergh, Antonio M. Persico, Anita L. Hawkins, Constance A. Griffin, Xiang Li, Ethylin Wang Jabs, George R. Uhl

Research output: Contribution to journalArticlepeer-review

627 Scopus citations

Abstract

The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3′ untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.

Original languageEnglish (US)
Pages (from-to)1104-1106
Number of pages3
JournalGenomics
Volume14
Issue number4
DOIs
StatePublished - Dec 1992

All Science Journal Classification (ASJC) codes

  • Genetics

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