Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

David J. Vandenbergh; Antonio M. Persico; Anita L. Hawkins; Constance A. Griffin; Xiang Li; Ethylin Wang Jabs; George R. Uhl

doi:10.1016/S0888-7543(05)80138-7

Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

David J. Vandenbergh
, Antonio M. Persico
, Anita L. Hawkins
, Constance A. Griffin
, Xiang Li
, Ethylin Wang Jabs
, George R. Uhl

Research output: Contribution to journal › Article › peer-review

636 Scopus citations

Abstract

The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3′ untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.

Original language	English (US)
Pages (from-to)	1104-1106
Number of pages	3
Journal	Genomics
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/S0888-7543(05)80138-7
State	Published - Dec 1992

All Science Journal Classification (ASJC) codes

Genetics

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10.1016/S0888-7543(05)80138-7

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title = "Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR",

abstract = "The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3′ untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.",

author = "Vandenbergh, \{David J.\} and Persico, \{Antonio M.\} and Hawkins, \{Anita L.\} and Griffin, \{Constance A.\} and Xiang Li and Jabs, \{Ethylin Wang\} and Uhl, \{George R.\}",

note = "Funding Information: for careful assistance with the manuscript, and the support from the intramural program of the National Institute of Drug Abuse and NIH Grants 5P01 GM1015-02 to E. W. Jabs and C. A. Griffin and DE10180 to E. W. Jabs.",

year = "1992",

month = dec,

doi = "10.1016/S0888-7543(05)80138-7",

language = "English (US)",

volume = "14",

pages = "1104--1106",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

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T1 - Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

AU - Vandenbergh, David J.

AU - Persico, Antonio M.

AU - Hawkins, Anita L.

AU - Griffin, Constance A.

AU - Li, Xiang

AU - Jabs, Ethylin Wang

AU - Uhl, George R.

N1 - Funding Information: for careful assistance with the manuscript, and the support from the intramural program of the National Institute of Drug Abuse and NIH Grants 5P01 GM1015-02 to E. W. Jabs and C. A. Griffin and DE10180 to E. W. Jabs.

PY - 1992/12

Y1 - 1992/12

N2 - The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3′ untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.

AB - The human dopamine transporter (DAT1) gene is localized to chromosome 5p15.3 by in situ hybridization and PCR amplification of rodent somatic cell hybrid DNA. Analysis of a 40-bp repeat in the 3′ untranslated region of the message revealed variable numbers of the repeat ranging from 3 to 11 copies. These results will aid in the investigation of a role for this gene in genetic disorders of the dopaminergic system in humans.

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UR - https://www.scopus.com/pages/publications/0027078061#tab=citedBy

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AN - SCOPUS:0027078061

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VL - 14

SP - 1104

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JO - Genomics

JF - Genomics

IS - 4

ER -

Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR

Abstract

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