TY - JOUR
T1 - Human genomic association studies
T2 - A primer for the infectious diseases specialist
AU - Motsinger, Alison A.
AU - Haas, David W.
AU - Hulgan, Todd
AU - Ritchie, Marylyn D.
N1 - Funding Information:
Financial support: National Institutes of Health (grant GM62758 to A.A.M., grant AT002508 to T.H., grant AG20135 to M.D.R., and grant RR 000095 to the Pharmacogenomics of Arrhythmia Therapy U01 site of the Pharmacogenetics Research Network); Vanderbilt AIDS Clinical Trials Unit (grant U01AI0694390 to D.W.H.); Vanderbilt Meharry Center for AIDS Research (grant P30AI054999 to D.W.H.); Pharmacogenomics of Arrhythmia Therapy U01 site of the Pharmacogenetics Research Network (grant HL65962 to M.D.R.).
PY - 2007/6/15
Y1 - 2007/6/15
N2 - Medical science is undergoing a genomic revolution. In coming years, insights from human genomic research will increasingly influence all aspects of infectious diseases, ranging from fundamental laboratory research and clinical care to epidemiology and global health. Infectious disease specialists unfamiliar with genomic methods and computational techniques may shy away from publications that involve human genomics analyses. In this article, we discuss selected aspects of study design and statistical analysis in this area, emphasizing important pitfalls that may compromise the validity of some studies. Our goal is to provide the infectious diseases specialist with information that will aid in the critical evaluation of publications that include human genomic analyses.
AB - Medical science is undergoing a genomic revolution. In coming years, insights from human genomic research will increasingly influence all aspects of infectious diseases, ranging from fundamental laboratory research and clinical care to epidemiology and global health. Infectious disease specialists unfamiliar with genomic methods and computational techniques may shy away from publications that involve human genomics analyses. In this article, we discuss selected aspects of study design and statistical analysis in this area, emphasizing important pitfalls that may compromise the validity of some studies. Our goal is to provide the infectious diseases specialist with information that will aid in the critical evaluation of publications that include human genomic analyses.
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U2 - 10.1086/518247
DO - 10.1086/518247
M3 - Review article
C2 - 17492588
AN - SCOPUS:34249907829
SN - 0022-1899
VL - 195
SP - 1737
EP - 1744
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 12
ER -