TY - JOUR
T1 - Human immunodeficiency virus type 1 infection in twin pairs infected at birth
AU - Biggar, Robert J.
AU - Janes, Michelle
AU - Pilon, Richard
AU - Roy, Reena
AU - Broadhead, Robin
AU - Kumwenda, Newton
AU - Taha, Taha E.T.
AU - Cassol, Sharon
PY - 2002/7/15
Y1 - 2002/7/15
N2 - Host genetic factors may influence the course of human immunodeficiency virus (HIV) infection. In Blantyre, Malawi, polymerase chain reaction was used to identify twin pairs who were concordantly HIV-1-infected in utero or perinatally and then to examine strain divergence or virus levels in identical and fraternal twin pairs. Among 315 twin pairs, both infants in 14 fraternal and 5 identical pairs were found to be infected at the same visit. Among 10 pairs, HIV-1 sequences were determined for both infants at ≥1 time point. HIV levels had a common profile in both fraternal and identical twin pairs. Identical twins were not always infected by the same quasi species, indicating that their mothers had multiple quasi species capable of infecting their infants. Subsequent viral divergence appears to depend on quasi-species stability rather than on genetically controlled host immune responses. Thus, given infection, factors intrinsic to HIV-1 are more important than host genetics in viral evolution.
AB - Host genetic factors may influence the course of human immunodeficiency virus (HIV) infection. In Blantyre, Malawi, polymerase chain reaction was used to identify twin pairs who were concordantly HIV-1-infected in utero or perinatally and then to examine strain divergence or virus levels in identical and fraternal twin pairs. Among 315 twin pairs, both infants in 14 fraternal and 5 identical pairs were found to be infected at the same visit. Among 10 pairs, HIV-1 sequences were determined for both infants at ≥1 time point. HIV levels had a common profile in both fraternal and identical twin pairs. Identical twins were not always infected by the same quasi species, indicating that their mothers had multiple quasi species capable of infecting their infants. Subsequent viral divergence appears to depend on quasi-species stability rather than on genetically controlled host immune responses. Thus, given infection, factors intrinsic to HIV-1 are more important than host genetics in viral evolution.
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U2 - 10.1086/341453
DO - 10.1086/341453
M3 - Article
C2 - 12134267
AN - SCOPUS:0037099370
SN - 0022-1899
VL - 186
SP - 281
EP - 285
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -