Human ovarian theca cells in culture

Jessica K. Wickenheisser; Velen L. Nelson-DeGrave; Janette McAllister

doi:10.1016/j.tem.2006.01.003

Human ovarian theca cells in culture

Jessica K. Wickenheisser, Velen L. Nelson-DeGrave, Janette McAllister

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

Elucidating the regulation of androgen biosynthesis in ovarian theca cells is not only important for determining the mechanisms of regulation of estrogen biosynthesis throughout the menstrual cycle, but is also essential for understanding the pathogenesis of excess androgen biosynthesis and polycystic ovary syndrome (PCOS). Human theca cells in primary and long-term culture have provided model systems for examining theca cell differentiation as well as the mechanisms underlying basal and cAMP-regulated steroid biosynthesis at both the transcriptional and post-transcriptional level in normal and PCOS ovaries. Results of these studies are expected to lead to the identification of novel targets for clinical treatment of infertility and PCOS.

Original language	English (US)
Pages (from-to)	65-71
Number of pages	7
Journal	Trends in Endocrinology and Metabolism
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.tem.2006.01.003
State	Published - Mar 2006

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.tem.2006.01.003

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title = "Human ovarian theca cells in culture",

abstract = "Elucidating the regulation of androgen biosynthesis in ovarian theca cells is not only important for determining the mechanisms of regulation of estrogen biosynthesis throughout the menstrual cycle, but is also essential for understanding the pathogenesis of excess androgen biosynthesis and polycystic ovary syndrome (PCOS). Human theca cells in primary and long-term culture have provided model systems for examining theca cell differentiation as well as the mechanisms underlying basal and cAMP-regulated steroid biosynthesis at both the transcriptional and post-transcriptional level in normal and PCOS ovaries. Results of these studies are expected to lead to the identification of novel targets for clinical treatment of infertility and PCOS.",

author = "Wickenheisser, {Jessica K.} and Nelson-DeGrave, {Velen L.} and Janette McAllister",

note = "Funding Information: This work was supported by NIH grants HD33852 and HD34449. We thank Margaret Hinshelwood and Karen Hendricks for their helpful comments and editorial assistance. ",

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AU - Wickenheisser, Jessica K.

AU - Nelson-DeGrave, Velen L.

AU - McAllister, Janette

N1 - Funding Information: This work was supported by NIH grants HD33852 and HD34449. We thank Margaret Hinshelwood and Karen Hendricks for their helpful comments and editorial assistance.

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Y1 - 2006/3

N2 - Elucidating the regulation of androgen biosynthesis in ovarian theca cells is not only important for determining the mechanisms of regulation of estrogen biosynthesis throughout the menstrual cycle, but is also essential for understanding the pathogenesis of excess androgen biosynthesis and polycystic ovary syndrome (PCOS). Human theca cells in primary and long-term culture have provided model systems for examining theca cell differentiation as well as the mechanisms underlying basal and cAMP-regulated steroid biosynthesis at both the transcriptional and post-transcriptional level in normal and PCOS ovaries. Results of these studies are expected to lead to the identification of novel targets for clinical treatment of infertility and PCOS.

AB - Elucidating the regulation of androgen biosynthesis in ovarian theca cells is not only important for determining the mechanisms of regulation of estrogen biosynthesis throughout the menstrual cycle, but is also essential for understanding the pathogenesis of excess androgen biosynthesis and polycystic ovary syndrome (PCOS). Human theca cells in primary and long-term culture have provided model systems for examining theca cell differentiation as well as the mechanisms underlying basal and cAMP-regulated steroid biosynthesis at both the transcriptional and post-transcriptional level in normal and PCOS ovaries. Results of these studies are expected to lead to the identification of novel targets for clinical treatment of infertility and PCOS.

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Human ovarian theca cells in culture

Abstract

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