Human ovarian theca cells in culture

Jessica K. Wickenheisser; Velen L. Nelson-DeGrave; Janette McAllister

doi:10.1016/j.tem.2006.01.003

Human ovarian theca cells in culture

Jessica K. Wickenheisser
, Velen L. Nelson-DeGrave
, Janette McAllister

Research output: Contribution to journal › Review article › peer-review

92 Scopus citations

Abstract

Elucidating the regulation of androgen biosynthesis in ovarian theca cells is not only important for determining the mechanisms of regulation of estrogen biosynthesis throughout the menstrual cycle, but is also essential for understanding the pathogenesis of excess androgen biosynthesis and polycystic ovary syndrome (PCOS). Human theca cells in primary and long-term culture have provided model systems for examining theca cell differentiation as well as the mechanisms underlying basal and cAMP-regulated steroid biosynthesis at both the transcriptional and post-transcriptional level in normal and PCOS ovaries. Results of these studies are expected to lead to the identification of novel targets for clinical treatment of infertility and PCOS.

Original language	English (US)
Pages (from-to)	65-71
Number of pages	7
Journal	Trends in Endocrinology and Metabolism
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.tem.2006.01.003
State	Published - Mar 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.1016/j.tem.2006.01.003

Cite this

@article{ddee14244513413cb7bfca85df30ae55,

title = "Human ovarian theca cells in culture",

abstract = "Elucidating the regulation of androgen biosynthesis in ovarian theca cells is not only important for determining the mechanisms of regulation of estrogen biosynthesis throughout the menstrual cycle, but is also essential for understanding the pathogenesis of excess androgen biosynthesis and polycystic ovary syndrome (PCOS). Human theca cells in primary and long-term culture have provided model systems for examining theca cell differentiation as well as the mechanisms underlying basal and cAMP-regulated steroid biosynthesis at both the transcriptional and post-transcriptional level in normal and PCOS ovaries. Results of these studies are expected to lead to the identification of novel targets for clinical treatment of infertility and PCOS.",

author = "Wickenheisser, \{Jessica K.\} and Nelson-DeGrave, \{Velen L.\} and Janette McAllister",

note = "Funding Information: This work was supported by NIH grants HD33852 and HD34449. We thank Margaret Hinshelwood and Karen Hendricks for their helpful comments and editorial assistance. ",

year = "2006",

month = mar,

doi = "10.1016/j.tem.2006.01.003",

language = "English (US)",

volume = "17",

pages = "65--71",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Human ovarian theca cells in culture

AU - Wickenheisser, Jessica K.

AU - Nelson-DeGrave, Velen L.

AU - McAllister, Janette

N1 - Funding Information: This work was supported by NIH grants HD33852 and HD34449. We thank Margaret Hinshelwood and Karen Hendricks for their helpful comments and editorial assistance.

PY - 2006/3

Y1 - 2006/3

N2 - Elucidating the regulation of androgen biosynthesis in ovarian theca cells is not only important for determining the mechanisms of regulation of estrogen biosynthesis throughout the menstrual cycle, but is also essential for understanding the pathogenesis of excess androgen biosynthesis and polycystic ovary syndrome (PCOS). Human theca cells in primary and long-term culture have provided model systems for examining theca cell differentiation as well as the mechanisms underlying basal and cAMP-regulated steroid biosynthesis at both the transcriptional and post-transcriptional level in normal and PCOS ovaries. Results of these studies are expected to lead to the identification of novel targets for clinical treatment of infertility and PCOS.

AB - Elucidating the regulation of androgen biosynthesis in ovarian theca cells is not only important for determining the mechanisms of regulation of estrogen biosynthesis throughout the menstrual cycle, but is also essential for understanding the pathogenesis of excess androgen biosynthesis and polycystic ovary syndrome (PCOS). Human theca cells in primary and long-term culture have provided model systems for examining theca cell differentiation as well as the mechanisms underlying basal and cAMP-regulated steroid biosynthesis at both the transcriptional and post-transcriptional level in normal and PCOS ovaries. Results of these studies are expected to lead to the identification of novel targets for clinical treatment of infertility and PCOS.

UR - https://www.scopus.com/pages/publications/33644501433

UR - https://www.scopus.com/pages/publications/33644501433#tab=citedBy

U2 - 10.1016/j.tem.2006.01.003

DO - 10.1016/j.tem.2006.01.003

M3 - Review article

C2 - 16460956

AN - SCOPUS:33644501433

SN - 1043-2760

VL - 17

SP - 65

EP - 71

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 2

ER -

Human ovarian theca cells in culture

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this