Abstract
A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.
Original language | English (US) |
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Pages (from-to) | 364-367 |
Number of pages | 4 |
Journal | Science |
Volume | 233 |
Issue number | 4761 |
DOIs | |
State | Published - 1986 |
All Science Journal Classification (ASJC) codes
- General