Human prion protein cDNA: Molecular cloning, chromosomal mapping, and biological implications

Y. U.Cheng J. Liao; Roger V. Lebo; Gary A. Clawson; Edward A. Smuckler

doi:10.1126/science.3014653

Human prion protein cDNA: Molecular cloning, chromosomal mapping, and biological implications

Y. U.Cheng J. Liao, Roger V. Lebo, Gary A. Clawson, Edward A. Smuckler

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117 Scopus citations

Abstract

A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.

Original language	English (US)
Pages (from-to)	364-367
Number of pages	4
Journal	Science
Volume	233
Issue number	4761
DOIs	https://doi.org/10.1126/science.3014653
State	Published - 1986

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title = "Human prion protein cDNA: Molecular cloning, chromosomal mapping, and biological implications",

abstract = "A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.",

author = "Liao, \{Y. U.Cheng J.\} and Lebo, \{Roger V.\} and Clawson, \{Gary A.\} and Smuckler, \{Edward A.\}",

year = "1986",

doi = "10.1126/science.3014653",

language = "English (US)",

volume = "233",

pages = "364--367",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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T1 - Human prion protein cDNA

T2 - Molecular cloning, chromosomal mapping, and biological implications

AU - Liao, Y. U.Cheng J.

AU - Lebo, Roger V.

AU - Clawson, Gary A.

AU - Smuckler, Edward A.

PY - 1986

Y1 - 1986

N2 - A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.

AB - A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.

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SP - 364

EP - 367

JO - Science

JF - Science

IS - 4761

ER -

Human prion protein cDNA: Molecular cloning, chromosomal mapping, and biological implications

Abstract

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