Human variants of O6-alkylguanine-DNA alkyltransferase

Anthony E. Pegg, Qingming Fang, Natalia A. Loktionova

    Research output: Contribution to journalReview articlepeer-review

    59 Scopus citations

    Abstract

    This article summarizes the current understanding of known variant forms of the MGMT gene that encode an altered protein. Epidemiological studies have been carried out to test whether these alterations are associated with altered cancer risk. Laboratory studies using recombinant proteins and cells expressing the known variants have investigated the possible effects of these sequence alterations on the ability of the encoded O6-alkylguanine-DNA alkyltransferase protein to protect cells from alkylation damage and to respond to therapeutic inactivators currently undergoing trials for cancer chemotherapy.

    Original languageEnglish (US)
    Pages (from-to)1071-1078
    Number of pages8
    JournalDNA Repair
    Volume6
    Issue number8
    DOIs
    StatePublished - Aug 1 2007

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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