TY - JOUR
T1 - Humoral and cell-mediated immunity to the intracellular pathogen Francisella tularensis
AU - Kirimanjeswara, Girish S.
AU - Olmos, Sofia
AU - Bakshi, Chandra S.
AU - Metzger, Dennis W.
PY - 2008/10
Y1 - 2008/10
N2 - Francisella tularensis can cause fatal respiratory tularemia in humans and animals and is increasingly being isolated in the United States and several European countries. The correlates of protective immunity against this intracellular bacterium are not known, and currently there are no licensed vaccines available for human use. Cell-mediated immunity has long been believed to be critical for protection, and the importance of humoral immunity is also now recognized. Furthermore, synergy between antibodies, T cell-derived cytokines, and phagocytes appears to be critical to achieve sterilizing immunity against F. tularensis. Thus, novel vaccine approaches should be designed to induce robust antibody and cell-mediated immune responses to this pathogen.
AB - Francisella tularensis can cause fatal respiratory tularemia in humans and animals and is increasingly being isolated in the United States and several European countries. The correlates of protective immunity against this intracellular bacterium are not known, and currently there are no licensed vaccines available for human use. Cell-mediated immunity has long been believed to be critical for protection, and the importance of humoral immunity is also now recognized. Furthermore, synergy between antibodies, T cell-derived cytokines, and phagocytes appears to be critical to achieve sterilizing immunity against F. tularensis. Thus, novel vaccine approaches should be designed to induce robust antibody and cell-mediated immune responses to this pathogen.
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U2 - 10.1111/j.1600-065X.2008.00689.x
DO - 10.1111/j.1600-065X.2008.00689.x
M3 - Review article
C2 - 18837786
AN - SCOPUS:52049121249
SN - 0105-2896
VL - 225
SP - 244
EP - 255
JO - Immunological Reviews
JF - Immunological Reviews
IS - 1
ER -