Deformable models have had great successes over the past 20 years in medical applications. We have recently developed new classes of deformable models which we term hybrid deformable models to automate the model initialization process and make improvements in segmentation and registration. In this paper we present several hybrid deformable methods we have been developing for segmentation and registration. These methods include Metamorphs, a novel shape and texture integration deformable model framework and the integration of deformable models with graphical models and learning methods. We first present a framework for the robust segmentation and tracking of the heart from tagged MRI images and second applications involving brain tumor segmentation as well as brain and cardiac shape registration.