TY - JOUR
T1 - Hybrid tissue scaffolds for controlled release applications
T2 - A study on design and fabrication of hybrid and heterogeneous tissue scaffolds for controlled release applications is presented in this paper
AU - Ozbolat, Ibrahim T.
AU - Khoda, A. K.M.B.
AU - Marchany, Michelle
AU - Gardella, Joseph A.
AU - Koc, Bahattin
N1 - Funding Information:
The research was partially funded by U.S. Army Medical Research Grant #: W81XWH-05-1-0401. The authors would like to thank Dr. Robert Hard in the Department of Pathology and Anatomical Sciences at University at Buffalo for micro-scale dark field image. The authors would like to thank the anonymous reviewers for their valuable comments and suggestions to improve the quality of the paper.
PY - 2012/3
Y1 - 2012/3
N2 - Spatiotemporal delivery of incorporated biological modifiers from synthesised tissue scaffolds has higher speculation to stimulate the complex tissue regeneration process via controlling the extracellular matrix. In this research, we consider the matrix material degradation profile, impregnated biological modifier and permeability of the structure to build hybrid tissue scaffolds based on tissue engineering requirements. Such hybrid structures are modelled, designed and fabricated to control release kinetics spatiotemporally for guided tissue regeneration. Firstly, a computer-aided biodegradation model is developed to simulate the degradation process of micro-patterned polymeric scaffolds. Secondly, scaffolds are biomimetically designed to control internal porous architecture with varying porosity. An optimised internal architecture scheme is developed to enhance permeability i.e. fluid transport to mediate release kinetics through the internal regions. Thirdly, heterogeneous scaffolds are developed with control composition of biomaterials and biological modifiers to synchronise the release kinetics with tissue regeneration. Proposed methods are implemented and illustrative examples are presented.
AB - Spatiotemporal delivery of incorporated biological modifiers from synthesised tissue scaffolds has higher speculation to stimulate the complex tissue regeneration process via controlling the extracellular matrix. In this research, we consider the matrix material degradation profile, impregnated biological modifier and permeability of the structure to build hybrid tissue scaffolds based on tissue engineering requirements. Such hybrid structures are modelled, designed and fabricated to control release kinetics spatiotemporally for guided tissue regeneration. Firstly, a computer-aided biodegradation model is developed to simulate the degradation process of micro-patterned polymeric scaffolds. Secondly, scaffolds are biomimetically designed to control internal porous architecture with varying porosity. An optimised internal architecture scheme is developed to enhance permeability i.e. fluid transport to mediate release kinetics through the internal regions. Thirdly, heterogeneous scaffolds are developed with control composition of biomaterials and biological modifiers to synchronise the release kinetics with tissue regeneration. Proposed methods are implemented and illustrative examples are presented.
UR - http://www.scopus.com/inward/record.url?scp=84859712044&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859712044&partnerID=8YFLogxK
U2 - 10.1080/17452759.2012.668700
DO - 10.1080/17452759.2012.668700
M3 - Article
AN - SCOPUS:84859712044
SN - 1745-2759
VL - 7
SP - 37
EP - 47
JO - Virtual and Physical Prototyping
JF - Virtual and Physical Prototyping
IS - 1
ER -