Hydroxocobalamin for vasoplegic syndrome in liver transplantation: Restoration of blood pressure without vasospasm

Harvey J. Woehlek; Brent T. Boettcher; Kathryn K. Lauer; David C. Cronin; Johnny C. Hong; Michael A. Zimmerman; Joohyun Kim; Motaz Selim

doi:10.1213/XAA.0000000000000398

Hydroxocobalamin for vasoplegic syndrome in liver transplantation: Restoration of blood pressure without vasospasm

Harvey J. Woehlek, Brent T. Boettcher, Kathryn K. Lauer, David C. Cronin, Johnny C. Hong, Michael A. Zimmerman, Joohyun Kim, Motaz Selim

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Systemic vasoplegia is common in patients undergoing liver transplantation. In this report, we present a case in which treatment with conventional vasopressors caused peripheral arterial spasm, rendering arterial blood pressure monitoring impossible. Administration of methylene blue resolved the vasospasm; however, concern for toxic dose requirements limited its use. Hydroxocobalamin administration resolved the vasospasm and increased blood pressure without the potential adverse effects seen with methylene blue. This case represents the first report of hydroxocobalamin use in liver transplantation and may represent a new option for the treatment of vasoplegia and the potential vasospasm that may result from traditional vasopressors.

Original language	English (US)
Title of host publication	100 Selected Case Reports from Anesthesia and Analgesia
Publisher	Wolters Kluwer Health
ISBN (Electronic)	9781975115333
ISBN (Print)	9781975115326
DOIs	https://doi.org/10.1213/XAA.0000000000000398
State	Published - Jan 1 2018

All Science Journal Classification (ASJC) codes

General Medicine

Access to Document

10.1213/XAA.0000000000000398

Cite this

@inbook{ff2d9b6f83e24074ba27820f52667a8b,

title = "Hydroxocobalamin for vasoplegic syndrome in liver transplantation: Restoration of blood pressure without vasospasm",

abstract = "Systemic vasoplegia is common in patients undergoing liver transplantation. In this report, we present a case in which treatment with conventional vasopressors caused peripheral arterial spasm, rendering arterial blood pressure monitoring impossible. Administration of methylene blue resolved the vasospasm; however, concern for toxic dose requirements limited its use. Hydroxocobalamin administration resolved the vasospasm and increased blood pressure without the potential adverse effects seen with methylene blue. This case represents the first report of hydroxocobalamin use in liver transplantation and may represent a new option for the treatment of vasoplegia and the potential vasospasm that may result from traditional vasopressors.",

author = "Woehlek, {Harvey J.} and Boettcher, {Brent T.} and Lauer, {Kathryn K.} and Cronin, {David C.} and Hong, {Johnny C.} and Zimmerman, {Michael A.} and Joohyun Kim and Motaz Selim",

note = "Publisher Copyright: {\textcopyright} 2019 by International Anesthesia Research Society.",

year = "2018",

month = jan,

day = "1",

doi = "10.1213/XAA.0000000000000398",

language = "English (US)",

isbn = "9781975115326",

booktitle = "100 Selected Case Reports from Anesthesia and Analgesia",

publisher = "Wolters Kluwer Health",

address = "Spain",

}

TY - CHAP

T1 - Hydroxocobalamin for vasoplegic syndrome in liver transplantation

T2 - Restoration of blood pressure without vasospasm

AU - Woehlek, Harvey J.

AU - Boettcher, Brent T.

AU - Lauer, Kathryn K.

AU - Cronin, David C.

AU - Hong, Johnny C.

AU - Zimmerman, Michael A.

AU - Kim, Joohyun

AU - Selim, Motaz

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Systemic vasoplegia is common in patients undergoing liver transplantation. In this report, we present a case in which treatment with conventional vasopressors caused peripheral arterial spasm, rendering arterial blood pressure monitoring impossible. Administration of methylene blue resolved the vasospasm; however, concern for toxic dose requirements limited its use. Hydroxocobalamin administration resolved the vasospasm and increased blood pressure without the potential adverse effects seen with methylene blue. This case represents the first report of hydroxocobalamin use in liver transplantation and may represent a new option for the treatment of vasoplegia and the potential vasospasm that may result from traditional vasopressors.

AB - Systemic vasoplegia is common in patients undergoing liver transplantation. In this report, we present a case in which treatment with conventional vasopressors caused peripheral arterial spasm, rendering arterial blood pressure monitoring impossible. Administration of methylene blue resolved the vasospasm; however, concern for toxic dose requirements limited its use. Hydroxocobalamin administration resolved the vasospasm and increased blood pressure without the potential adverse effects seen with methylene blue. This case represents the first report of hydroxocobalamin use in liver transplantation and may represent a new option for the treatment of vasoplegia and the potential vasospasm that may result from traditional vasopressors.

UR - http://www.scopus.com/inward/record.url?scp=85064840657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064840657&partnerID=8YFLogxK

U2 - 10.1213/XAA.0000000000000398

DO - 10.1213/XAA.0000000000000398

M3 - Chapter

AN - SCOPUS:85064840657

SN - 9781975115326

BT - 100 Selected Case Reports from Anesthesia and Analgesia

PB - Wolters Kluwer Health

ER -

Hydroxocobalamin for vasoplegic syndrome in liver transplantation: Restoration of blood pressure without vasospasm

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this