TY - JOUR
T1 - HYPER
T2 - pre-clinical device for spatially-confined magnetic particle hyperthermia
AU - Carlton, Hayden
AU - Weber, Matthias
AU - Peters, Maximilian
AU - Arepally, Nageshwar
AU - Lad, Yash Sharad
AU - Jaswal, Anshul
AU - Ivkov, Robert
AU - Attaluri, Anilchandra
AU - Goodwill, Patrick
N1 - Publisher Copyright:
© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2023
Y1 - 2023
N2 - Purpose: Magnetic particle hyperthermia is an approved cancer treatment that harnesses thermal energy generated by magnetic nanoparticles when they are exposed to an alternating magnetic field (AMF). Thermal stress is either directly cytotoxic or increases the susceptibility of cancer cells to standard therapies, such as radiation. As with other thermal therapies, the challenge with nanoparticle hyperthermia is controlling energy delivery. Here, we describe the design and implementation of a prototype pre-clinical device, called HYPER, that achieves spatially confined nanoparticle heating within a user-selected volume and location. Design: Spatial control of nanoparticle heating was achieved by placing an AMF generating coil (340 kHz, 0–15 mT), between two opposing permanent magnets. The relative positions between the magnets determined the magnetic field gradient (0.7 T/m–2.3 T/m), which in turn governed the volume of the field free region (FFR) between them (0.8–35 cm3). Both the gradient value and position of the FFR within the AMF ([−14, 14]x, [−18, 18]y, [−30, 30]z) mm are values selected by the user via the graphical user interface (GUI). The software then controls linear actuators that move the static magnets to adjust the position of the FFR in 3D space based on user input. Within the FFR, the nanoparticles generate hysteresis heating; however, outside the FFR where the static field is non-negligible, the nanoparticles are unable to generate hysteresis loss power. Verification: We verified the performance of the HYPER to design specifications by independently heating two nanoparticle-rich areas of a phantom placed within the volume occupied by the AMF heating coil.
AB - Purpose: Magnetic particle hyperthermia is an approved cancer treatment that harnesses thermal energy generated by magnetic nanoparticles when they are exposed to an alternating magnetic field (AMF). Thermal stress is either directly cytotoxic or increases the susceptibility of cancer cells to standard therapies, such as radiation. As with other thermal therapies, the challenge with nanoparticle hyperthermia is controlling energy delivery. Here, we describe the design and implementation of a prototype pre-clinical device, called HYPER, that achieves spatially confined nanoparticle heating within a user-selected volume and location. Design: Spatial control of nanoparticle heating was achieved by placing an AMF generating coil (340 kHz, 0–15 mT), between two opposing permanent magnets. The relative positions between the magnets determined the magnetic field gradient (0.7 T/m–2.3 T/m), which in turn governed the volume of the field free region (FFR) between them (0.8–35 cm3). Both the gradient value and position of the FFR within the AMF ([−14, 14]x, [−18, 18]y, [−30, 30]z) mm are values selected by the user via the graphical user interface (GUI). The software then controls linear actuators that move the static magnets to adjust the position of the FFR in 3D space based on user input. Within the FFR, the nanoparticles generate hysteresis heating; however, outside the FFR where the static field is non-negligible, the nanoparticles are unable to generate hysteresis loss power. Verification: We verified the performance of the HYPER to design specifications by independently heating two nanoparticle-rich areas of a phantom placed within the volume occupied by the AMF heating coil.
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U2 - 10.1080/02656736.2023.2272067
DO - 10.1080/02656736.2023.2272067
M3 - Article
C2 - 37875265
AN - SCOPUS:85174922282
SN - 0265-6736
VL - 40
JO - International Journal of Hyperthermia
JF - International Journal of Hyperthermia
IS - 1
M1 - 2272067
ER -