Hyperexcitability following moderate hypoxia in hippocampal tissue slices

Steven Schiff, George G. Somjen

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


The effects of moderate hypoxia on CA1 pyramidal cells were studied in submerged rat hippocampal tissue slices. Hyperexcitability developed during re-oxygenation following 30-45 min of hypoxia at 29 °C. During hypoxia a sustained increase in extracellular potassium was observed. The post-hypoxic hyperexcitability of CA1 neurons may be the result of their inability to fully recover intracellular potassium lost during oxygen deprivation.

Original languageEnglish (US)
Pages (from-to)337-340
Number of pages4
JournalBrain research
Issue number2
StatePublished - Jul 1 1985

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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