Abstract
The effects of moderate hypoxia on CA1 pyramidal cells were studied in submerged rat hippocampal tissue slices. Hyperexcitability developed during re-oxygenation following 30-45 min of hypoxia at 29 °C. During hypoxia a sustained increase in extracellular potassium was observed. The post-hypoxic hyperexcitability of CA1 neurons may be the result of their inability to fully recover intracellular potassium lost during oxygen deprivation.
Original language | English (US) |
---|---|
Pages (from-to) | 337-340 |
Number of pages | 4 |
Journal | Brain research |
Volume | 337 |
Issue number | 2 |
DOIs | |
State | Published - Jul 1 1985 |
All Science Journal Classification (ASJC) codes
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology