Hyperexcitability following moderate hypoxia in hippocampal tissue slices

Steven Schiff; George G. Somjen

doi:10.1016/0006-8993(85)90071-X

Hyperexcitability following moderate hypoxia in hippocampal tissue slices

Steven Schiff
, George G. Somjen

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

The effects of moderate hypoxia on CA1 pyramidal cells were studied in submerged rat hippocampal tissue slices. Hyperexcitability developed during re-oxygenation following 30-45 min of hypoxia at 29 °C. During hypoxia a sustained increase in extracellular potassium was observed. The post-hypoxic hyperexcitability of CA1 neurons may be the result of their inability to fully recover intracellular potassium lost during oxygen deprivation.

Original language	English (US)
Pages (from-to)	337-340
Number of pages	4
Journal	Brain Research
Volume	337
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(85)90071-X
State	Published - Jul 1 1985

All Science Journal Classification (ASJC) codes

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(85)90071-X

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title = "Hyperexcitability following moderate hypoxia in hippocampal tissue slices",

abstract = "The effects of moderate hypoxia on CA1 pyramidal cells were studied in submerged rat hippocampal tissue slices. Hyperexcitability developed during re-oxygenation following 30-45 min of hypoxia at 29 °C. During hypoxia a sustained increase in extracellular potassium was observed. The post-hypoxic hyperexcitability of CA1 neurons may be the result of their inability to fully recover intracellular potassium lost during oxygen deprivation.",

author = "Steven Schiff and Somjen, \{George G.\}",

note = "Funding Information: The advice and assistance of P. G. Aitken and A. L. Sylvia has been very much appreciated. Supported by the Research Foundation of the American Association of Neurological Surgery and USPHS Grant NS 18670.",

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AU - Schiff, Steven

AU - Somjen, George G.

N1 - Funding Information: The advice and assistance of P. G. Aitken and A. L. Sylvia has been very much appreciated. Supported by the Research Foundation of the American Association of Neurological Surgery and USPHS Grant NS 18670.

PY - 1985/7/1

Y1 - 1985/7/1

N2 - The effects of moderate hypoxia on CA1 pyramidal cells were studied in submerged rat hippocampal tissue slices. Hyperexcitability developed during re-oxygenation following 30-45 min of hypoxia at 29 °C. During hypoxia a sustained increase in extracellular potassium was observed. The post-hypoxic hyperexcitability of CA1 neurons may be the result of their inability to fully recover intracellular potassium lost during oxygen deprivation.

AB - The effects of moderate hypoxia on CA1 pyramidal cells were studied in submerged rat hippocampal tissue slices. Hyperexcitability developed during re-oxygenation following 30-45 min of hypoxia at 29 °C. During hypoxia a sustained increase in extracellular potassium was observed. The post-hypoxic hyperexcitability of CA1 neurons may be the result of their inability to fully recover intracellular potassium lost during oxygen deprivation.

UR - https://www.scopus.com/pages/publications/0022256156

UR - https://www.scopus.com/pages/publications/0022256156#tab=citedBy

U2 - 10.1016/0006-8993(85)90071-X

DO - 10.1016/0006-8993(85)90071-X

M3 - Article

C2 - 2992681

AN - SCOPUS:0022256156

SN - 0006-8993

VL - 337

SP - 337

EP - 340

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Hyperexcitability following moderate hypoxia in hippocampal tissue slices

Abstract

All Science Journal Classification (ASJC) codes

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