Hyperferritinemic sepsis: An opportunity for earlier diagnosis and intervention?

E. Scott Halstead, Surender Rajasekaran, Julie C. Fitzgerald, Scott L. Weiss

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


We describe a case of an infant with HSV meningitis and septic shock who demonstrated a remarkably high serum ferritin level. Aggressive pediatric intensive care and the administration of high-dose glucocorticoids were not able to reverse the multiple organ dysfunctions. Subsequent autopsy identified the presence of hemophagocytosis, thus the patient fulfilled hemophagocytic lymphohistiocytosis (HLH) criteria post-mortem. This case highlights that serum ferritin may be an important early indicator of mortality in sepsis due to a cytokine storm similar to macrophage activation syndrome and HLH.

Original languageEnglish (US)
Article number77
JournalFrontiers in Pediatrics
Issue numberAUG
StatePublished - Aug 1 2016

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


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