TY - JOUR
T1 - Hyperferritinemic sepsis
T2 - An opportunity for earlier diagnosis and intervention?
AU - Halstead, E. Scott
AU - Rajasekaran, Surender
AU - Fitzgerald, Julie C.
AU - Weiss, Scott L.
N1 - Publisher Copyright:
© 2016 Halstead, Rajasekaran, Fitzgerald and Weiss.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - We describe a case of an infant with HSV meningitis and septic shock who demonstrated a remarkably high serum ferritin level. Aggressive pediatric intensive care and the administration of high-dose glucocorticoids were not able to reverse the multiple organ dysfunctions. Subsequent autopsy identified the presence of hemophagocytosis, thus the patient fulfilled hemophagocytic lymphohistiocytosis (HLH) criteria post-mortem. This case highlights that serum ferritin may be an important early indicator of mortality in sepsis due to a cytokine storm similar to macrophage activation syndrome and HLH.
AB - We describe a case of an infant with HSV meningitis and septic shock who demonstrated a remarkably high serum ferritin level. Aggressive pediatric intensive care and the administration of high-dose glucocorticoids were not able to reverse the multiple organ dysfunctions. Subsequent autopsy identified the presence of hemophagocytosis, thus the patient fulfilled hemophagocytic lymphohistiocytosis (HLH) criteria post-mortem. This case highlights that serum ferritin may be an important early indicator of mortality in sepsis due to a cytokine storm similar to macrophage activation syndrome and HLH.
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U2 - 10.3389/fped.2016.00077
DO - 10.3389/fped.2016.00077
M3 - Article
AN - SCOPUS:85062020266
SN - 2296-2360
VL - 4
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
IS - AUG
M1 - 77
ER -