Hypertrophic Cardiomyopathy 2020

James Kogut, Eric D. Popjes

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Purpose of Review: To briefly review the pathophysiology and natural history of hypertrophic cardiomyopathy (HCM) and to describe the diagnosis, assessment, and contemporary management strategies. Recent Findings: HCM-related mortality remains low; however, symptoms due in large part to LVOT obstruction remain a clinical dilemma. Several medical therapies have been shown to reduce symptoms and improve functional capacity, including several recent phase 2 clinical trials involving the novel myosin modulator mavacamten. In patients with refractory symptoms, septal reduction therapy or advanced therapies remain viable options in many cases. Summary: HCM is a complex and heterogeneous disease with diverse presentations and variable anatomy and clinical outcomes. The majority of patients will remain asymptomatic or with minimal symptoms and long-term survival remains high. For symptomatic patients, a variety of medical therapies, along with septal reduction therapies, have been shown to reduce symptoms and improve functional capacity.

Original languageEnglish (US)
Article number154
JournalCurrent Cardiology Reports
Issue number11
StatePublished - Nov 1 2020

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Hypertrophic Cardiomyopathy 2020'. Together they form a unique fingerprint.

Cite this