Hypertrophic, Hypersecretory Protein-losing Gastropathy

A patient who presented with the clinical manifestations of hypoproteinemia and in whom gastric hyperrugosity was associated with excessive gastric protein loss and acid hypersecretion is reported. Atropine sulfate markedly reduced both the hypersecretion and gastric protein loss. It is suggested that anticholinergic therapy be considered in any patient with a protein-losing gastropathy of nonmalignant etiology in whom high, normal, and perhaps even subnormal acid secretion is found following maximal histamine stimulation.