Hypoaldosteronism

Hypoaldosteronism is a congenital or acquired condition of insufficient production of aldosterone by the adrenal cortex, leading to diminished aldosterone-mediated synthesis of Na+–K+-exchanging ATPase in renal tubular cells. Clinical symptoms include hyperkalemia, sodium-wasting, hypotension, and sometimes metabolic acidosis. Hypoaldosteronism may coexist with other adrenocortical deficiencies such as hypocortisolism (Addison's disease) or occur independently.