TY - JOUR
T1 - Hypoglycemic effect of polysaccharides of Dendrobium officinale compound on type 2 diabetic mice
AU - Li, Chen
AU - Wang, Yunwei
AU - Huang, Zijia
AU - Zhang, Yi
AU - Li, Jiao
AU - Zhang, Qing
AU - Simpson, Benjamin Kofi
AU - Wang, Jingxue
N1 - Funding Information:
The research was supported by Shanxi Province Biotechnology Academician Workstation, International Cooperation Project of Key Research and Development Program of Shanxi Province (201803D421016), the Basic Research Program (Free Exploration) of Shanxi Province (202203021221015) and the Open Project Program of Xinghuacun College of Shanxi (Shanxi Institute of Brewing Technology and Industry (Preparation)) (No. XCS-UK-202215). We thank Prof. Samuel S.M. Sun, School of Life Science, Chinese University of Hong Kong, for his guidance during this research.
Publisher Copyright:
© 2023 The Authors
PY - 2023/7
Y1 - 2023/7
N2 - This study investigated the hypoglycemic effect of polysaccharides of Dendrobium officinale compound (DOCP) on streptozotocin induced type 2 diabetic mice. Compared with the model group, the fasting blood glucose value of DOCP (800 mg/kg) at day 35 of the study significantly decreased (P < 0.05). Meanwhile, DOCP (800 mg/kg) significantly increased the serum insulin content and reduced the insulin resistance in type 2 diabetic mice. Furthermore, DOCP reduced the serum total cholesterol, triglyceride and LDL-C concentrations, increased the antioxidant capability, and improved liver and pancreas damage in type 2 diabetic mice. DOCP increased the diversity of intestinal flora composition, and the abundance of beneficial bacteria such as Lactobacillus and Bifidobacteriaceae. DOCP (800 mg/kg) induced up-regulation expression of genes such as Glut2, Gck, Pklr, Insr, Pdx-1 and Ins1, but elicited down-regulation of Caspase-3. These results indicate that DOCP achieves antidiabetic and hypolipidemic effects in type 2 diabetic mice.
AB - This study investigated the hypoglycemic effect of polysaccharides of Dendrobium officinale compound (DOCP) on streptozotocin induced type 2 diabetic mice. Compared with the model group, the fasting blood glucose value of DOCP (800 mg/kg) at day 35 of the study significantly decreased (P < 0.05). Meanwhile, DOCP (800 mg/kg) significantly increased the serum insulin content and reduced the insulin resistance in type 2 diabetic mice. Furthermore, DOCP reduced the serum total cholesterol, triglyceride and LDL-C concentrations, increased the antioxidant capability, and improved liver and pancreas damage in type 2 diabetic mice. DOCP increased the diversity of intestinal flora composition, and the abundance of beneficial bacteria such as Lactobacillus and Bifidobacteriaceae. DOCP (800 mg/kg) induced up-regulation expression of genes such as Glut2, Gck, Pklr, Insr, Pdx-1 and Ins1, but elicited down-regulation of Caspase-3. These results indicate that DOCP achieves antidiabetic and hypolipidemic effects in type 2 diabetic mice.
UR - https://www.scopus.com/pages/publications/85160263923
UR - https://www.scopus.com/pages/publications/85160263923#tab=citedBy
U2 - 10.1016/j.jff.2023.105579
DO - 10.1016/j.jff.2023.105579
M3 - Article
AN - SCOPUS:85160263923
SN - 1756-4646
VL - 106
JO - Journal of Functional Foods
JF - Journal of Functional Foods
M1 - 105579
ER -
