Hypoxia-Inducible factor-1 promotes pancreatic ductal adenocarcinoma invasion and metastasis by activating transcription of the actin-Bundling protein fascin

Keyphrases

• Metastasis 100%
• Hypoxia-inducible factor-1α (HIF-1α) 100%
• Pancreatic Ductal Adenocarcinoma 100%
• Actin-binding Proteins 100%
• Fascin 100%
• Overexpression 35%
• Pancreatic Duct Cells 17%
• Expression Level 11%
• Hypoxia 11%
• Cell Invasion 11%
• Matrix metalloproteinase-2 (MMP-2) 11%
• Protein Kinase 5%
• In Cancer 5%
• Molecular Mechanism 5%
• Local Infiltration 5%
• Early Onset 5%
• Knockdown 5%
• 5-year Survival 5%
• Extracellular Signal-regulated Kinase 5%
• Malignant Tumor 5%
• Immunohistochemical Staining 5%
• Cell Migration 5%
• Cancer Tissue 5%
• Direct Target 5%
• Colocalization 5%
• RNA Transcription 5%
• Distant Metastasis 5%
• Hypoxic Tumor Microenvironment 5%
• Hypoxia Response Element 5%

Biochemistry, Genetics and Molecular Biology

• Transcription 100%
• Actin 100%
• Hypoxia Inducible Factor 1 100%
• Fascin 100%
• Cell Invasion 11%
• Gelatinase A 11%
• MMP2 11%
• Protein Kinase C 5%
• Promoter Region 5%
• Survival Rate 5%
• Extracellular Signal-Regulated Kinases 5%
• Response Element 5%
• Cell Migration 5%
• Messenger RNA 5%

Neuroscience

• MMP2 11%