I Heard These Medications Give You Cancer. Is That True? Risks of Malignancy with IBD Therapy

“Thiopurines (azathioprine and mercaptopurine) and biologic anti-TNF agents (infliximab, adalimumab, certolizumab, and golimumab) are some of the most effective medications that we have for treating inflammatory bowel disease. However, it is important to recognize that these therapies have been associated with an increase in the risk of developing certain cancers including lymphoma and skin cancer. Fortunately, the total number of people who develop these cancers while on therapy is very small. There is also little evidence that thiopurines and anti-TNF drugs significantly increase the risk of other types of cancers. Before initiating treatment with these types of medications, we need to review your cancer risks and weigh them against the considerable benefits these therapies can offer.”