TY - GEN
T1 - ICAM-1 ve polymorfonötrofil ligandi olan fibrin molekülü nün deǧişen akiş koşullarinda melanoma adhezyonuna etkisi
AU - Özdemir, Tuǧba
AU - Dong, Cheng
PY - 2009
Y1 - 2009
N2 - One of the predominant cause of cancer patient death is the metastatic spread of tumor cells. The leading step in melanoma extravasation is the tumor cell adhesion to the endothelium of the capillaries. However, melanoma cells do not express the appropriate adhesion molecules to bind to an activated endothelium. Previous studies have found neutrophils facilitate melanoma cell adhesion under dynamic flow conditions throught the binding of ICAM-1 on melanoma cells and β 2 integrins on PMNs. In addition, soluble fibrin (sFn) is a marker for propagated intravascular coagulation and have a dramatical increase in cancer patients' laboratory coagulation inspections . Soluble fibrin molecule has both receptors for Mac-1 on PMNs and ICAM-1 on tumor cell surface which may affect the tumor cell adherence to endothelial wall surface via PMN. The objective of this study is to investigate the role of soluble fibrin on PMN facilitated tumor cell adherence to endothelial wall and how different effects of hydrodynamic shear stress and shear rate affects the force of adhesion to vessel wall.
AB - One of the predominant cause of cancer patient death is the metastatic spread of tumor cells. The leading step in melanoma extravasation is the tumor cell adhesion to the endothelium of the capillaries. However, melanoma cells do not express the appropriate adhesion molecules to bind to an activated endothelium. Previous studies have found neutrophils facilitate melanoma cell adhesion under dynamic flow conditions throught the binding of ICAM-1 on melanoma cells and β 2 integrins on PMNs. In addition, soluble fibrin (sFn) is a marker for propagated intravascular coagulation and have a dramatical increase in cancer patients' laboratory coagulation inspections . Soluble fibrin molecule has both receptors for Mac-1 on PMNs and ICAM-1 on tumor cell surface which may affect the tumor cell adherence to endothelial wall surface via PMN. The objective of this study is to investigate the role of soluble fibrin on PMN facilitated tumor cell adherence to endothelial wall and how different effects of hydrodynamic shear stress and shear rate affects the force of adhesion to vessel wall.
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U2 - 10.1109/BIYOMUT.2009.5130385
DO - 10.1109/BIYOMUT.2009.5130385
M3 - Conference contribution
AN - SCOPUS:70350238327
SN - 9781424436064
T3 - Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009
BT - Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009
T2 - 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009
Y2 - 20 May 2009 through 22 May 2009
ER -
