ICAM-1 ve polymorfonötrofil ligandi olan fibrin molekülü nün deǧişen akiş koşullarinda melanoma adhezyonuna etkisi

Tuǧba Özdemir; Cheng Dong

doi:10.1109/BIYOMUT.2009.5130385

ICAM-1 ve polymorfonötrofil ligandi olan fibrin molekülü nün deǧişen akiş koşullarinda melanoma adhezyonuna etkisi

Translated title of the contribution: The role of fibrin as a ligand for ICAM-1 and PMN in melanoma adhesion under different shear conditions

Tuǧba Özdemir
, Cheng Dong

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

One of the predominant cause of cancer patient death is the metastatic spread of tumor cells. The leading step in melanoma extravasation is the tumor cell adhesion to the endothelium of the capillaries. However, melanoma cells do not express the appropriate adhesion molecules to bind to an activated endothelium. Previous studies have found neutrophils facilitate melanoma cell adhesion under dynamic flow conditions throught the binding of ICAM-1 on melanoma cells and β ₂ integrins on PMNs. In addition, soluble fibrin (sFn) is a marker for propagated intravascular coagulation and have a dramatical increase in cancer patients' laboratory coagulation inspections . Soluble fibrin molecule has both receptors for Mac-1 on PMNs and ICAM-1 on tumor cell surface which may affect the tumor cell adherence to endothelial wall surface via PMN. The objective of this study is to investigate the role of soluble fibrin on PMN facilitated tumor cell adherence to endothelial wall and how different effects of hydrodynamic shear stress and shear rate affects the force of adhesion to vessel wall.

Translated title of the contribution	The role of fibrin as a ligand for ICAM-1 and PMN in melanoma adhesion under different shear conditions
Original language	Turkish
Title of host publication	Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009
DOIs	https://doi.org/10.1109/BIYOMUT.2009.5130385
State	Published - 2009
Event	2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009 - Balcova, Izmir, Turkey Duration: May 20 2009 → May 22 2009

Publication series

Name	Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009

Conference

Conference	2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009
Country/Territory	Turkey
City	Balcova, Izmir
Period	5/20/09 → 5/22/09

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Biomedical Engineering
Pharmacology (medical)
Radiology Nuclear Medicine and imaging

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10.1109/BIYOMUT.2009.5130385

Cite this

Özdemir, T., & Dong, C. (2009). ICAM-1 ve polymorfonötrofil ligandi olan fibrin molekülü nün deǧişen akiş koşullarinda melanoma adhezyonuna etkisi. In Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009 Article 5130385 (Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009). https://doi.org/10.1109/BIYOMUT.2009.5130385

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title = "ICAM-1 ve polymorfon{\"o}trofil ligandi olan fibrin molek{\"u}l{\"u} n{\"u}n deǧi{\c s}en aki{\c s} ko{\c s}ullarinda melanoma adhezyonuna etkisi",

abstract = "One of the predominant cause of cancer patient death is the metastatic spread of tumor cells. The leading step in melanoma extravasation is the tumor cell adhesion to the endothelium of the capillaries. However, melanoma cells do not express the appropriate adhesion molecules to bind to an activated endothelium. Previous studies have found neutrophils facilitate melanoma cell adhesion under dynamic flow conditions throught the binding of ICAM-1 on melanoma cells and β 2 integrins on PMNs. In addition, soluble fibrin (sFn) is a marker for propagated intravascular coagulation and have a dramatical increase in cancer patients' laboratory coagulation inspections . Soluble fibrin molecule has both receptors for Mac-1 on PMNs and ICAM-1 on tumor cell surface which may affect the tumor cell adherence to endothelial wall surface via PMN. The objective of this study is to investigate the role of soluble fibrin on PMN facilitated tumor cell adherence to endothelial wall and how different effects of hydrodynamic shear stress and shear rate affects the force of adhesion to vessel wall.",

author = "Tuǧba {\"O}zdemir and Cheng Dong",

year = "2009",

doi = "10.1109/BIYOMUT.2009.5130385",

language = "Turkish",

isbn = "9781424436064",

series = "Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009",

booktitle = "Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009",

note = "2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009 ; Conference date: 20-05-2009 Through 22-05-2009",

}

Özdemir, T & Dong, C 2009, ICAM-1 ve polymorfonötrofil ligandi olan fibrin molekülü nün deǧişen akiş koşullarinda melanoma adhezyonuna etkisi. in Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009., 5130385, Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009, 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009, Balcova, Izmir, Turkey, 5/20/09. https://doi.org/10.1109/BIYOMUT.2009.5130385

ICAM-1 ve polymorfonötrofil ligandi olan fibrin molekülü nün deǧişen akiş koşullarinda melanoma adhezyonuna etkisi. / Özdemir, Tuǧba; Dong, Cheng.
Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009. 2009. 5130385 (Proceedings of 2009 14th National Biomedical Engineering Meeting, BIYOMUT 2009).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - ICAM-1 ve polymorfonötrofil ligandi olan fibrin molekülü nün deǧişen akiş koşullarinda melanoma adhezyonuna etkisi

AU - Özdemir, Tuǧba

AU - Dong, Cheng

PY - 2009

Y1 - 2009

N2 - One of the predominant cause of cancer patient death is the metastatic spread of tumor cells. The leading step in melanoma extravasation is the tumor cell adhesion to the endothelium of the capillaries. However, melanoma cells do not express the appropriate adhesion molecules to bind to an activated endothelium. Previous studies have found neutrophils facilitate melanoma cell adhesion under dynamic flow conditions throught the binding of ICAM-1 on melanoma cells and β 2 integrins on PMNs. In addition, soluble fibrin (sFn) is a marker for propagated intravascular coagulation and have a dramatical increase in cancer patients' laboratory coagulation inspections . Soluble fibrin molecule has both receptors for Mac-1 on PMNs and ICAM-1 on tumor cell surface which may affect the tumor cell adherence to endothelial wall surface via PMN. The objective of this study is to investigate the role of soluble fibrin on PMN facilitated tumor cell adherence to endothelial wall and how different effects of hydrodynamic shear stress and shear rate affects the force of adhesion to vessel wall.

AB - One of the predominant cause of cancer patient death is the metastatic spread of tumor cells. The leading step in melanoma extravasation is the tumor cell adhesion to the endothelium of the capillaries. However, melanoma cells do not express the appropriate adhesion molecules to bind to an activated endothelium. Previous studies have found neutrophils facilitate melanoma cell adhesion under dynamic flow conditions throught the binding of ICAM-1 on melanoma cells and β 2 integrins on PMNs. In addition, soluble fibrin (sFn) is a marker for propagated intravascular coagulation and have a dramatical increase in cancer patients' laboratory coagulation inspections . Soluble fibrin molecule has both receptors for Mac-1 on PMNs and ICAM-1 on tumor cell surface which may affect the tumor cell adherence to endothelial wall surface via PMN. The objective of this study is to investigate the role of soluble fibrin on PMN facilitated tumor cell adherence to endothelial wall and how different effects of hydrodynamic shear stress and shear rate affects the force of adhesion to vessel wall.

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ER -

ICAM-1 ve polymorfonötrofil ligandi olan fibrin molekülü nün deǧişen akiş koşullarinda melanoma adhezyonuna etkisi

Abstract

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