Identification and location of brain protein 4.1

Steven R. Goodman; Linda A. Casoria; Diane B. Coleman; Ian S. Zagon

doi:10.1126/science.6374897

Identification and location of brain protein 4.1

Steven R. Goodman, Linda A. Casoria, Diane B. Coleman, Ian S. Zagon

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65 Scopus citations

Abstract

Protein 4.1 is a membrane skeletal protein that converts the low-affinity interaction between spectrin and act in into a high-affinity ternary complex of spectrin, protein 4.1, and actin that is essential to the structural stability of the erythrocyte. Pig brain was shown to contain an 87-kilodalton immunoreactive analog of protein 4.1 that has partial sequence homology with pig erythrocyte protein 4.1 and the same location as spectrin in the cortical cytoplasm of neuronal and glial cell types of the cerebellum.

Original language	English (US)
Pages (from-to)	1433-1436
Number of pages	4
Journal	Science
Volume	224
Issue number	4656
DOIs	https://doi.org/10.1126/science.6374897
State	Published - 1984

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abstract = "Protein 4.1 is a membrane skeletal protein that converts the low-affinity interaction between spectrin and act in into a high-affinity ternary complex of spectrin, protein 4.1, and actin that is essential to the structural stability of the erythrocyte. Pig brain was shown to contain an 87-kilodalton immunoreactive analog of protein 4.1 that has partial sequence homology with pig erythrocyte protein 4.1 and the same location as spectrin in the cortical cytoplasm of neuronal and glial cell types of the cerebellum.",

author = "Goodman, {Steven R.} and Casoria, {Linda A.} and Coleman, {Diane B.} and Zagon, {Ian S.}",

year = "1984",

doi = "10.1126/science.6374897",

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T1 - Identification and location of brain protein 4.1

AU - Goodman, Steven R.

AU - Casoria, Linda A.

AU - Coleman, Diane B.

AU - Zagon, Ian S.

PY - 1984

Y1 - 1984

N2 - Protein 4.1 is a membrane skeletal protein that converts the low-affinity interaction between spectrin and act in into a high-affinity ternary complex of spectrin, protein 4.1, and actin that is essential to the structural stability of the erythrocyte. Pig brain was shown to contain an 87-kilodalton immunoreactive analog of protein 4.1 that has partial sequence homology with pig erythrocyte protein 4.1 and the same location as spectrin in the cortical cytoplasm of neuronal and glial cell types of the cerebellum.

AB - Protein 4.1 is a membrane skeletal protein that converts the low-affinity interaction between spectrin and act in into a high-affinity ternary complex of spectrin, protein 4.1, and actin that is essential to the structural stability of the erythrocyte. Pig brain was shown to contain an 87-kilodalton immunoreactive analog of protein 4.1 that has partial sequence homology with pig erythrocyte protein 4.1 and the same location as spectrin in the cortical cytoplasm of neuronal and glial cell types of the cerebellum.

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EP - 1436

JO - Science

JF - Science

IS - 4656

ER -

Identification and location of brain protein 4.1

Abstract

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